10 Best flea and tick treatment for cats (2025)

10 Best flea and tick treatment for cats in 2025 offer effective solutions to keep your feline friend safe from pesky parasites. These treatments include topical solutions, oral medications, and collars designed to provide long-lasting protection. Popular options feature ingredients like fipronil and imidacloprid, known for their efficacy against fleas and ticks. Brands such as Frontline, Advantage, and Seresto lead the market with innovative formulations that cater to various lifestyles and sensitivities. Always consult your veterinarian to choose the best product tailored to your cat's needs, ensuring a happy and healthy life free from infestations.

SaleBestseller No. 1

Frontline Plus Flea and Tick Treatment for Cats Over 1.5 lbs. 3 Treatments

FRONTLINE Plus for Cats provides waterproof, fast-acting, long-lasting flea and tick protection that's proven to kill fleas, flea eggs, flea larvae, chewing lice, and ticks that can transmit Lyme disease
Break the flea life cycle with FRONTLINE Plus for Cats, specially formulated with fipronil and (S)-methoprene to kill existing adult fleas, flea eggs and flea larvae to guard against further infestations for flea & tick control
Trusted by pet owners for over 20 years, FRONTLINE Plus for Cats can be used on kittens as young as eight weeks old, weighing 1.5 pounds or more; One monthly dose provides protection from fleas & ticks for a full 30 days
Even indoor dogs need flea and tick control because you or other pets in the household may bring fleas into the home; These fleas can lead to a flea infestation
FRONTLINE Plus also comes in a formula designed for dogs and puppies, 8 weeks and older, weighing 5 lbs and over, providing the same reliable flea & tick protection

Bestseller No. 2

Amazon Basics Flea and Tick Topical Treatment for Cats (over 1.5 lbs), 6 Count (Previously Solimo)

Same product, new look―This product is identical in manufacturing and formulation as the Solimo brand
One 6 dose pack of Amazon Basics Flea & Tick Treatment for Cats (over 1.5 lbs)
Amazon Basics Flea & Tick starts eliminating fleas and ticks within 24 hours of treatment
Active ingredients (list ingredients) prevent flea infestations by killing flea eggs, flea larvae, mosquitos, biting flies and chewing lice
One application provides up to 30 days of protection

Bestseller No. 3

Advantage II Large Cat Vet-Recommended Flea Treatment & Prevention | Cats Over 9 lbs. | 1-Month Supply

Advantage II Large Cat is a leading brand in cat flea treatment and prevention for large cats over 9 lbs., at least 8 weeks of age
Vet-recommended, easy-to-apply monthly topical treatment – no hard-to-swallow pills, no prescription needed
Delivers total flea protection – kills adult fleas, flea larvae and flea eggs through contact
Same-day effectiveness – kills fleas within 12 hours of application and keeps working for 30 days
Fragrance-free formula, waterproof after 24 hours of application

Bestseller No. 4

TevraPet FirstAct Plus Flea and Tick Topical for Cats over 1.5lbs, 3 Dose Waterproof Flea and Tick Control/Prevention for 3 Months

Proven formula - Contains fipronil and (S)-Methoprene, the same active ingredients as Frontline Plus for cats
Effective - This flea and tick topical kills fleas, flea eggs and larvae, chewing lice, and all stages of ticks including those that may transmit Lyme disease
Waterproof - use on your cat monthly, no need to reapply after swimming or bathing
3 month supply - includes 3 applicators for 3 months of flea and tick Prevention; Apply these flea drops Once every 30 days
Trusted quality - made in Germany in a certified eu-gmp facility, tested to meet rigorous standards of quality and consistency

Bestseller No. 5

PetArmor Plus Flea and Tick Prevention for Cats, Cat Flea and Tick Treatment, 6 Dose, Waterproof Topical, Fast Acting, Cats Over 1.5 lbs

EFFECTIVE, WATERPROOF FLEA TREATMENT FOR CATS: PetArmor Plus is a waterproof, flea & tick topical prevention for cats that kills fleas, flea eggs, flea larvae, ticks, and chewing lice for up to 30 days after application.
TRUSTED, VET QUALITY FORMULA: Containing fipronil and (S)-methoprene, the same active ingredients as FRONTLINE Plus for Cats. PetArmor Plus for Cats has a powerful formula that starts to kill fleas within 24 hours.
BREAK THE FLEA CYCLE: Unlike other flea and tick treatments that may temporarily suppress flea activity, PETARMOR Plus Cat Flea Treatment works by effectively breaking the flea life cycle. Kill flea eggs and larvae to prevent re-infestation.
FLEA AND TICK PROTECTION: PetArmor Plus for Cats flea drops protects your furry family members from brown dog ticks, American dog ticks, Lone Star ticks, and deer ticks (which may transmit Lyme disease).
EASY-TO-USE, LONG-LASTING: PetArmor Plus flea and tick treatment comes with six (6) waterproof topical applications that provide your pet flea protection and control for (6) months

SaleBestseller No. 6

Hartz UltraGuard Topical Flea & Tick Prevention for Cats and Kittens - 3 Monthly Treatments

Topical drop formula kills fleas and deer ticks
Includes 3 monthly treatments in easy to apply, single dose tubes
Repels mosquitoes for 18 days
For use on cats and kittens 12 weeks and older weighing 5 pounds and over

Bestseller No. 7

Amazon Basics Flea Topical for Large Cats (over 9 pounds), 4 Count (Previously Solimo)

FAST-ACTING FLEA MEDICATION FOR CATS: Eliminates fleas in just 12 hours, providing your large cat with swift relief from discomfort with our effective flea medication for cats
LONG-LASTING FLEA PREVENTION FOR CATS: Protect your cat from infestations for up to 4 weeks with each application of this flea remover, providing continuous and reliable flea prevention for cats
TOPICAL CAT FLEA DROPS FOR REINFESTATION: This cat flea medicine proactively kills reinfesting fleas within 2 hours, efficiently halting the flea lifecycle
SUITABLE CAT FLEA MEDS FOR LARGE CATS: Specifically formulated for cats weighing over 9 pounds, offering targeted flea control with our dedicated cat flea meds for your furry companion
SUITABLE CAT FLEA MEDS FOR LARGE CATS: Specifically formulated for cats weighing over 9 pounds, offering targeted flea control with our dedicated cat flea meds for your furry companion

Bestseller No. 8

Seresto Cat Vet-Recommended Flea & Tick Treatment & Prevention Collar for Cats | 8 Months Protection

Vet-recommended, premium flea & tick protection for cats & kittens without the price tag
Long-lasting flea and tick collar kills & repels fleas for 8 continuous months
Seresto is the #1 veterinarian recommended flea & tick collar*
Starts working within 24 hours to kill & repel fleas and ticks by contact so pests don’t have to bite your cat to die
Hassle-free, non-greasy, easy-to-use flea & tick protection

SaleBestseller No. 9

PetArmor for Cats, Flea & Tick Treatment for Cats (Over 1.5 Pounds), Includes 3 Month Supply of Topical Flea Treatments

CAT FLEA AND TICK CONTROL: SENTRY Fiproguard topical flea and tick prevention for cats kills fleas, ticks and chewing lice for up to 30 days.
VET QUALITY FORMULA: SENTRY Fiproguard is a vet-quality formula flea treatment that contains the active ingredient fipronil.
FOR KITTENS AND CATS: PetArmor topical flea treatment for cats and kittens 8 weeks and older for up to 30 days after application and helps prevents infestations of adult fleas.
FLEA AND TICK PREVENTION: PetArmor for cats helps you protect your furry family member from the diseases fleas and ticks carry, including deer ticks that may transmit Lyme disease.
INCLUDES: Three (3) 0.017 fl. oz. waterproof topical applications for cat flea and tick control. For best results, apply flea and tick treatment for cats directly to dry skin on your cats back, between the shoulder blades, on a monthly basis.

Bestseller No. 10

PetArmor Plus Flea and Tick Prevention for Cats, Cat Flea and Tick Treatment, 1 Dose, Waterproof Topical, Fast Acting, Cats Over 1.5 lbs

Effective, Waterproof Flea Treatment for Cats: PetArmor plus topical flea and tick Prevention for cats kills fleas, flea eggs, flea larvae, ticks, and chewing lice for up to 30 days after application
Trusted, Vet Quality* Formula: this vet-quality formula flea treatment contains fipronil and begins killing fleas & ticks within 24 hours
Break the Flea Cycle: Unlike other flea and tick treatments that may temporarily suppress flea activity, PETARMOR Plus Cat Flea Treatment works by effectively breaking the flea life cycle! Kill flea eggs and larvae to prevent re-infestation
Fast-Acting Long-Lasting Flea and tick Protection: PetArmor plus for cats helps you protect your furry family member from the diseases fleas and ticks carry, including deer ticks that may transmit Lyme disease
Easy-to-Use, Long-Lasting: PetArmor Plus flea and tick treatment comes with one (1) waterproof topical application that provide your pet flea protection and control for one (1) months

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