10 Best folate supplement (2025)

Folate supplements are essential for supporting overall health, particularly for pregnant women and those looking to boost their nutrient intake. In 2025, the 10 best folate supplements stand out for their quality and effectiveness. These top-rated options include brands that offer bioavailable forms of folate, such as L-methylfolate, ensuring optimal absorption. Many of these supplements are also free from common allergens and additives, making them suitable for various dietary needs. With a focus on purity and potency, these folate supplements can help individuals meet their daily requirements and promote healthy cellular function.

SaleBestseller No. 1

Life Extension BioActive Folate & Vitamin B12, Promotes Heart, Brain & GI Tract Health, Non-GMO, Gluten-Free, Vegetarian, 90 Capsules

Folate in the body – 5-MTHF is the metabolically active form of folic acid and supports healthy DNA function, helps maintain normal homocysteine levels, and supports GI and immune function.
Benefits of vitamin B12 – B12 is a vital member of the vitamin B family. The biologically active form of B12, methylcobalamin, supports cognitive health, nerve cell growth and metabolism.
The importance of vitamin B – These two biologically active forms of B9 and B12 ensure that you are covering your bases and getting the many benefits of these forms of vitamin B.
Ingredients matter – We use the finest raw ingredients with the quality and purity you deserve. The majority of our products are non-GMO, gluten-free and manufactured in the USA—and a Certificate of Analysis is available for every one.     
Live your healthiest life – We believe the answers to a healthier life are in reach, and that scientific research is the key to getting there. That’s why so many of our formulas feature specific ingredients and amounts based on scientific studies.

Bestseller No. 2

Life Extension Optimized Folate – L-methylfolate – Heart & Brain Support, Healthy Homocysteine Levels – Non-GMO, Gluten-Free, Vegetarian – 1700 mcg DFE, 100 Vegetarian Tablets

Get a brain boost – Stay proactive about your brain health and support optimal cognitive function with this folate supplement. This 1700 mcg vitamin B formula helps maintain healthy cognition—especially as you age.
Pump up the heart health – This 5-MTHF supplement is a cardiovascular health superstar! Folate helps maintain already-normal homocysteine levels, an important cardiovascular health marker. Folate is a great way to keep heart health in check.
Metabolically active form – 5-MTHF, the metabolically active form of folate, is good for your heart and brain health. But not everyone can convert the dietary form of folate (known as folic acid) into 5-MTHF. This supplement provides folate’s 5-MTHF form.
Ingredients matter – We use only the finest raw ingredients with the purity and potency you deserve. The majority of our products are non-GMO, gluten-free and manufactured in the USA—and a Certificate of Analysis is available for every one.
Live your healthiest life – We believe the answers to a healthier life are within reach, and that scientific research is the key to getting us there. That’s why so many of our formulas feature specific ingredients and amounts based on scientific studies.

SaleBestseller No. 3

Nature Made Folic Acid 400 mcg (665 mcg DFE), Dietary Supplement for Nervous System Function, 250 Tablets, 250 Day Supply

Nervous system support supplement: contains one 250 count bottle of Nature Made Folic Acid 400 mcg (665 mcg DFE) Tablets for a 250-day supply
This Folic Acid supplement contains an important B vitamin for women of childbearing age and pregnant women
These Folic acid supplements support nervous system function, and play a critical role in the proper development of the baby's nervous system
Adults take one of these Folic Acid tablets daily with water and a meal
These gluten free Folic Acid vitamins for women have no color added, no artificial flavors and no preservatives

SaleBestseller No. 4

Doctor's Best Fully Active Folate with Quatrefolic400 mcg, Healthy Mood, Memory, Circulation, Well-Being, 90 VC

Quatrefolic contains the natural form of folic acid. It is the most bioavailable form of folate that provides greater stability and water solubility.
Quatrefolic is the metabolically active folate, making it more efficient than folic acid for maximized benefits.
Folate is an essential vitamin to support DNA
Helps support cardiovascular, mental, and emotional well-being

SaleBestseller No. 5

NOW Foods Supplements, Methyl Folate 1,000 mcg, Metabolically Active Folate*, Co-Enzyme B Vitamin, 90 Tablets

CO-ENZYME B VITAMIN/1,000 mg TABLETS: Methylfolate is the biologically active, naturally occurring form of folate that is used for fundamental body functions like normal cell division and the synthesis of neurotransmitters and DNA.
METABOLICALLY ACTIVE FOLATE/SUPERIOR BIOAVAILABLITY: Quatrefolic is a patented form of methylfolate that has demonstrated bioavailability superior to that of folate from dietary sources.
CERTIFICATIONS/CLASSIFICATIONS: Non-GMO, Vegan/Vegetarian
GMP Quality Assured: NPA A-rated GMP certification means that every aspect of the NOW manufacturing process has been examined, including our laboratory/testing methods (for stability, potency, and product formulation).
Packaged in the USA by a family owned and operated company since 1968

Bestseller No. 6

THORNE 5-MTHF - Methylfolate (Active B9 Folate) Supplement - Supports Cardiovascular Health, Fetal Development, Nerve Health, Methylation, and Homocysteine Levels - 60 Capsules - 5-MTHF 1mg

Healthy Methylation: A breakthrough in active folate supplementation for healthy methylation*
Positivity: Supports a healthy outlook*
Nerves & Circulation: Supports healthy blood vessel and nerve function*
Cardiovascular Support: Providing the nutritional cofactors for optimal homocysteine metabolism supports cardiovascular health*
Trusted: Thorne is chosen by champions and trusted by 100+ pro teams. Thorne is the only supplement manufacturer to collaborate with Mayo Clinic on wellness research and content. Thorne is also a proud partner of 11 U.S. Olympic Teams

SaleBestseller No. 7

Solgar Folate 1000 mcg, 120 Tablets - 1000 mcg Bio-active Metafolin - Heart Health - Vegan, Gluten Free, Dairy Free, Kosher - 120 Servings

BODY READY – In order for the body to use Folic Acid, it must undergo a series of biochemical steps. The active folate in Solgar Folate is Metafolin (L-methyfolate) which is bioidentical to the bioactive form, which means no conversion by the body.
BENEFITS – The active folate in this formulation helps in promoting heart health as well as providing support for a healthy nervous system as well as the formulation of healthy red blood cells.
SUITABLE FOR VEGANS – All capsules are non-GMO and certified gluten free. They are also free of wheat, dairy, soy, yeast, sugar, sodium, artificial flavors, sweeteners, preservatives and colors.
The Gold Standard; For over 70 years, Solgar has been committed to quality, health, and well-being. Our mission is to create the finest nutritional supplements in small batches, through tireless research, using only the finest raw materials

Bestseller No. 8

Methylfolate 1,000mcg, 120 Capsules (Third Party Tested Methyl Folate Supplement) Methylated Folate is a More Active Form of Folate Than Folic Acid (Non-GMO, Vegan Safe) by Double Wood

METHYL FOLATE 1,000MCG VS FOLIC ACID 1,000MCG - Recent research suggests that l methylfolate is a more active form of folate when compared to folic acid. Folic acid is the synthetic form of Folate
METABOLICALLY ACTIVE 5-MTHF (OPTIMZED FOLATE) - L Methyl Folate is the biological and active form of folate. It is more immediately absorbed into the bloodstream and requires little processing by the body
METHYLFOLATE vs METHYL B12 - Methyl folate and Methyl B12 are both metabolically active forms of B Vitamins and are far more bioavailable when compared to their non-methylated counterparts
VEGAN SAFE, Manufactured in the USA from Globally Sourced Ingredients, NON-GMO, GLUTEN FREE - Double Wood's L Methylfolate capsules are vegan safe, Manufactured in the USA from Globally Sourced Ingredients, Gluten Free, and Non-GMO
SATIFSACTION ASSURED - If you aren't happy with the product for any reason please contact us and we promise to make things right

Bestseller No. 9

Spring Valley Folate Dietary Supplement | Folate Supplement for Women Pregnancy | Acido Folico para Mujer Embarazada | Folic Acid 800 | 400 Count Bundle with Lual's 45 Diabetes Decoded

Ebook - Lual's 45 Diabetes Decoded included, Copyright TX 9-328-789 - ISBN 9798863095257
✅ Promotes overall health and wellbeing: Spring Valley's Folate Dietary Supplement is a high-potency supplement designed to support your body's needs. Each tablet contains 1,333mcg of folate, an essential nutrient that plays a critical role in various bodily functions.
✅ Helps support the creation of red and white blood cells: Folate is an essential nutrient that helps support the creation of red and white blood cells. This can help to promote healthy circulation and a strong immune system.
✅ Essential for proper growth and development: Folate is essential for the proper growth and development of the body. It helps to support the creation of DNA and RNA, which are essential for the growth and repair of all bodily tissues.
✅ Suitable for vegetarians: Spring Valley's Folate Dietary Supplement is suitable for vegetarians, as it does not contain any animal-derived ingredients.

Bestseller No. 10

Pure Encapsulations Folate 400 | Metafolin L-5-MTHF Supplement to Support Cardiovascular, Cellular, and Neural Health* | 90 Capsules

Naturally Occurring Folate: Folate 400 provides Metafolin (L-5-MTHF), the naturally occurring, universally metabolized form of folate.*
Folate is essential in fetal development and plays an important role in the maintenance of muscle tone in the G.I. tract, the functioning of the nervous system, and the integrity of skin, hair, and the liver.*
Cellular Health: Adequate folate intake may provide significant cardiovascular, cellular and neural support.*
Pure Quality: Our supplements are made with only premium ingredients sourced from trusted suppliers and guided by our nutritional experts, then carefully manufactured and tested to verify their potency and purity.
Pure Difference: What makes us different isn't just our process or what goes into our supplements -- what we leave out matters, too. Pure Encapsulations products are FREE FROM wheat, eggs, tree nuts & peanuts, gluten, artificial colors, flavors & sweeteners, coatings and shellacs, GMOs, and unnecessary binders, fillers & preservatives.

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