10 Best digestive enzymes for weight loss (2025)

10 best digestive enzymes for weight loss in 2025 include a variety of powerful supplements designed to enhance digestion and promote fat loss. These enzymes, such as bromelain, papain, and lipase, help break down proteins, carbohydrates, and fats more efficiently, leading to improved nutrient absorption and reduced bloating. Additionally, enzymes like amylase and cellulase support the metabolism of complex carbohydrates and fiber, respectively. Incorporating these digestive aids into your routine can optimize your digestive health, boost energy levels, and facilitate weight management, making them essential for anyone looking to achieve their weight loss goals effectively.

SaleBestseller No. 1

Physician's CHOICE Digestive Enzymes - Multi Enzymes, Organic Prebiotics & Probiotics for Digestive Health & Gut Health - Meal Time Discomfort Relief & Bloating - Dual Action Approach - 60 CT

Beat the Bloat & Say Goodbye to Meal Time Discomfort: 16 beneficial enzymes that digest proteins, carbs, fruits, veggies, beans, dairy, & fats to cover all diets. With SBO Probiotics & Prebiotics to aid digestion further - Your New Meal Time Hack!
Dual Action Relief: Our powerful digestive enzymes aid with breaking down food while the prebiotics & probiotics promote digestive function in the gut. They work synergistically to provide relief from mealtime discomfort.
Probiotics that Survive the Gut: Formulated with 3 soil-based probiotic strains - specifically selected due to their ability to survive the harsh gut environment. Along with Organic Prebiotics that fuel the growth of healthy bacteria in the gut.
Science Backed - Our Digestive Enzyme Probiotics are crafted based on scientific research. We have partnered with expert physicians to help review our products & research. We strive to educate & help you with informed decisions regarding your health.
Safety Assured Standard of Quality: Our Digestive Enzymes are 3rd-party tested for purity and potency. Each bottle is manufactured w/ love & care in the USA with strict quality control - using imported & domestic ingredients. No Refrigeration Needed

SaleBestseller No. 2

Zenwise Health Digestive Enzymes for Gut Health - Probiotic Multi Enzymes with Prebiotics and Probiotics for Women and Men for Digestive Health and Bloating Relief, Daily Enzymes for Digestion -180 CT

3-in-1 Formula – Blend of lab proven enzymes, clinically proven probiotics and prebiotics works synergistically to break down proteins, fats, and carbs while resorting digestive flora balance for optimal nutrient absorption and digestion maintain digestive wellness and promote regularity
Fast-Acting Enzymes – Powerful enzyme blend starts working immediately to break down food up to 39% more completely, and ease indigestion for rapid, noticeable relief
Proven Probiotics – Guaranteed to arrive alive and work within hours in the small intestine where 90% of nutrient absorption occurs
Gas & Bloating Relief - Targeted enzymes work with beneficial microflora to ease uncomfortable bloating, reduce gas, and soothe digestive discomfort naturally
Plant-Based Formula - Pure vegetarian enzymes combined with prebiotic fiber nourish your microbiome while supporting healthy digestion and immune function – take 1 capsule before your meal to experience digestive delight

Bestseller No. 3

NOW Foods Supplements, Super Enzymes, Formulated with Bromelain, Ox Bile, Pancreatin and Papain,180 Capsules

SUPPORTS HEALTHY DIGESTION*: NOW Super Enzymes is a comprehensive blend of enzymes that supports healthy digestion.* Take one capsule with a meal.
BREAKS DOWN FATS, CARBS, AND PROTEINS*/OPTIMIZES NUTRIENT AVAILABILITY*: Formulated with bromelain, ox bile, pancreatin and papain, Super Enzymes helps to optimize the breakdown of fats, carbohydrates and protein.*
CERTIFICATIONS/CLASSIFICATIONS: Soy Free, Made without Gluten, Keto Friendly
GMP Quality Assured: NPA A-rated GMP certification means that every aspect of the NOW manufacturing process has been examined, including our laboratory/testing methods (for stability, potency, and product formulation).
Packaged in the USA by a family owned and operated company since 1968.

SaleBestseller No. 4

Enzymedica Lypo Gold, Digestive Enzymes for Fat Digestion, Offers Fast Acting Gas & Bloating Relief, 60 Count

Fat Digestion Expert: Packed with the fat-digesting Lipase enzyme, Lypo Gold efficiently breaks down a wide range of fatty foods, whether they're the healthy fats in avocado and salmon or the greasy indulgences in fried treats, burgers and more
Keto-Friendly Companion: Helpful for keto dieters and those without gallbladders, this supplement breaks down fatty foods, carbs and proteins, relieving gas and bloating*
Effective All the Way Through: Our proprietary Thera-blend enzymes are formulated for optimal activity throughout the digestive system's varying pH levels, providing faster relief and maximum digestive support*
Dosage: Just 1 capsule daily breaks down up to 78g fat, 4g protein and 32g carbs; Take more than 1 capsule as needed; Contains no gluten, milk, casein, soy, egg, artificial colors, flavors, or GMOs; Vegan, Kosher and Clean Label Project Certified
Making a Difference: Enzymedica products harness the power of the finest natural ingredients for maximum effectiveness; We create quality products without compromise while championing initiatives that support the well-being of people and our planet

SaleBestseller No. 5

Garden of Life Dr Formulated Digestive Enzymes with Papain, Bromelain, Lipase for Digestion & Nutrient Absorption – Organic Digest+ - Vegan, Gluten-Free, Non-GMO, Tropical Fruit Flavor, 90 Chewables

BREAK IT DOWN: Organic Digest+ offers 29 Certified Organic fruits and vegetables plus a select blend of 13 powerful digestive enzymes including amylase, bromelain, and lactase to help with digestion after meals
MADE FROM WHOLE FOODS: Dr. Perlmutter formulated Digest+ to be a full spectrum plant-based enzyme formula to aid the digestion of proteins, fats, and carbs; We’ve also included prebiotic fiber from Organic Acacia to support the good bacteria in your gut
BACKED BY SCIENCE: Our Dr. Formulated Organic Digest+ is the first-ever Certified Organic and Non-GMO digestive enzyme formula that is made from real food and is delivered using Clean Tablet Technology to ensure optimal nutrient absorption
CONVENIENCE IN MIND: Transport to the tropics after every last bite; Enjoy the benefits of Organic Digest+ in a tropical flavored, shelf stable tablet thats size makes it easy to take on the go; Adults chew 1 tablet after each meal or snack
EXPERTLY FORMULATED: Our digestive supplement is proudly Dr. Formulated by David Perlmutter, MD and Third-Party Certified Non-GMO, Gluten-Free and Vegan; Made in the USA with no dairy, soy, gluten, peanuts or tree nuts

Bestseller No. 6

NatureBell Digestive Enzymes with Probiotics and Prebiotics, 240 Veggie Capsules | Gut & Digestive Health Support – 20 Enzyme & 5 Prebiotic Pancreatic Enzyme Complex | Non-GMO, Vegan Friendly

Digestive Enzyme and Prebiotic complex with 240 veggie capsules, one capsule serving for an 8-month supply, take one per meal daily for up to three meals for the first week, then only once daily after that for optimal benefits.
Each serving delivers 400mg total, combining 20 enzymes with 5 prebiotics including 200mg of psyllium husk, inulin, acacia senegal, FOS, and chia seed, as well as 200mg of carbs, proteins, fibers, fats, and lactose enzymes.
Designed for both women and men, this full spectrum blend supports digestion, nutrient absorption, bloating, and overall gut health.
A synergistic mix that may promote a balanced gut flora, providing daily digestive balance with its unique combination of enzymes and prebiotics.
Authentic non-GMO digestive enzyme supplement. Contains pure ingredients free of soy, dairy, gluten, wheat, preservatives, eggs, fish, and tree nuts. All products are also 3rd party lab tested for safety and potency.

Bestseller No. 7

Digestive Enzymes - 800mg Blend of All 10 Most Essential Digestive and Pancreatic Enzymes (Amylase, Lipase, Bromelain, Lactase, Papain, Protease, Cellulase, Maltase, Invertase) by Double Wood

CONTAINS ALL 10 MOST ESSENTIAL DIGESTIVE ENZYMES: No other digestive enzyme blend contains all 10 most essential digestive enzymes including Amylase, Lipase, Bromelain, Lactase, Papain, Protease, Cellulase, Maltase, Invertase, and Glucoamylase
TOP 3 PANCREATIC ENZYMES INCLUDED: The Amylase pancreatic enzyme breaks down starches and carbohydrates into sugars. The Lipase enzyme breaks down fats and oils, into glycerol and fatty acids. Lastly, the Protease enzymes break down proteins into amino acids
VITAZYME DIGESTIVE AID: Double Wood's trademarked digestive enzyme supplement aids digestion and supports overall digestive health. Delivering super enzymes to help with bloating relief
BREAKDOWN PROTEIN, FATS, AND CARBOHYDRATES: Double Wood's Vitazyme blend contains the most essential digestive and pancreatic enzymes needed to break down fats, proteins, and carbohydrates
WE BOTTLE WELLNESS: At Double Wood we provide pure, potent supplements that deliver exceptional value, all backed by careful sourcing and rigorous third-party testing

SaleBestseller No. 8

HUM Flatter Me Digestive Enzymes Bloating Supplement - Fast-Acting Bloat Relief for Digestive Health & Debloating Multi Enzyme | Bloat Pills, Anti Bloat Pills, Vegan 60 Servings

Fast-acting, 30 Minute Debloat Formula– Combat bloating in just 30 minutes with our blend of 18 full-spectrum digestive enzymes like lipase, amylase, and bromelain, designed to break down proteins, carbs, fats, and fiber, promoting digestive health and bloating relief for women.
Natural Triple Herb Blend For Digestion Support – Our fast-acting formula is enhanced with a natural triple herb blend of ginger, peppermint, and fennel to support healthy digestion and nutrient absorption.
Clinically Tested Results You Can Feel – Flatter Me’s advanced digestive enzyme blend is clinically shown to reduce bloating in 30 minutes and by up to 2 inches after just one use.*
Clean and Clinically Studied. HUM products are Clean Label Project Certified, non-GMO, and rigorously tested to meet the highest standards of safety and quality, free from artificial flavors, sweeteners and colors.
How To Take – Take one capsule with a meal.

Bestseller No. 9

Wholesome Wellness Digestive Enzymes 1000MG Plus Prebiotics & Probiotics Supplement, 180 Capsules, Organic Plant-Based Vegan Formula for Digestion & Lactose with Amylase & Bromelain,3-6 Months Supply

Get Digestive Comfort Now – Ultra Strength 1000 MG Dose of clinical grade digestive enzymes and a 10 billion CFU 10 strain probiotic with prebiotics. Get results & relief fast with more than double the dose of other digestive enzyme supplements. Using organic, systemic, Dr. formulated, & plant based ingredients to ensure the best healthy digestion for adult men & women. Anti bloating, flatulence, fat, pancreatic, & bowel cleansing with Turmeric, Ginger, Papaya, Pectin, Bladderwrack & more.
Goodbye Hard-to-Digest Foods – This formula features our Advanced Multi Enzyme System to help you digest fried, spicy, raw, processed food, dairy, protein, salts, carb / carbohydrate, vitamin and acidic diet fruits and veggies. Immune-Boosting Probiotic – The gut, biofilm & gallbladder is home to 50% of the body’s immune repair response and this supplement contains a powerful 10 billion CFU dose of 10 different probiotic strains clinically shown to enhance preventions & immune system response.
Relieve Gas, Belly Bloating / Bloat, Constipation, Leaky, Indigestion, Reflux, Belching & Acid Discomfort! Aid gut health, beauty & bloated stomach comfort. Prebiotic fiber, probiotic encapsulation(Lactobacillus acidophilus, plantarum, casei, salivarius, bulgaricus and Bifidobacterium lactis, bifidum, breve, longum), & enzymes support gut flora bacteria, bile, nutrient absorption, motility, & enzyme levels your body isn't producing as you age.
Complete digestive enzyme pills complex blend with essential organic blue agave heart, inulin, amylase / amilasa, papain, protease A, invertase, cellulase, hemicellulase, lactase, lipase / lipasa, alpha-galactosidase, fungal pepsin, glucomylase, & bromelina & bromelain supplement. Plus your probiotic supplement and prebiotic supplement (pre & pro) at the same time. All in a convenient purified cap / capsule form which you can open and take as a chewable with dietary nutrients, super food or meal
Proudly made in the USA in a GMP certified manufacturing facility, 3rd Party Tested, and a 100% satisfaction money back guarantee. If you are not satisfied with our products for any reason, let us know and we’ll make it right. This product is vegan, non-GMO, pure, natural, gluten free, cGMP, wise, dairy free, zen, organic ingredients and is free of soy, peanuts, eggs, gelatin, ox, shellfish, artificial sweeteners, colors, & flavors.

Bestseller No. 10

Pure Encapsulations Digestive Enzymes Ultra with Betaine HCl - Vegetarian Digestive Enzyme Supplement to Support Protein, Carb, Fiber, and Dairy Digestion* - 180 Capsules

Nutrient Absorption: Contains a mixture of vegetarian enzymes developed to support nutrient bioavailability and absorption; supports digestion*
Supports Digestion: Facilitates the normal breakdown of proteins, peptides, polysaccharides, and disaccharides; assists with dairy, fiber, and protein digestion*
Digestive Enzymes: Offers a broad-spectrum combination of vegetarian digestive enzymes designed to provide optimal activity across a wide pH range
Enhanced Enzyme Blend: Experience enhanced digestion aid with Betaine HCI; supports optimal gastric pH for normal breakdown of many food types*
Pure Difference: What we leave out matters, too; Pure Encapsulations products are free from common allergens, artificial or unnecessary ingredients, and GMOs

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