10 Best peptide serum (2025)

10 Best peptide serums in 2025 offer a revolutionary approach to skincare, harnessing the power of peptides to enhance skin health and appearance. These serums are formulated to boost collagen production, reduce fine lines, and improve skin elasticity, making them essential for any anti-aging regimen. Top contenders include brands renowned for their innovative formulations and high-quality ingredients, ensuring effective results. With options catering to various skin types and concerns, these peptide serums promise to rejuvenate and nourish, providing a youthful glow. Discover the transformative benefits of these serums and elevate your skincare routine to new heights.

SaleBestseller No. 1

COSRX 6X Peptide Collagen Booster Toner Serum, Niacinamide & Hyaluronic Acid Skin Renewal Boosting Facial Essence for All Skin Types, Korean Skin Care, Paraben Free, 150mL/5.07 Fl.Oz

Skin Booster Toner: Skin Boosting Serum with 6 Peptides that improve skin elasticity, fine lines, pores, and radiance. Boost your skin's condition and achieve multiple benefits with this serum.
First Step of Skincare: This lightweight serum with a toner-like texture absorbs quickly into the skin, making it a great first step in your daily skincare routine. Its quick absorption allows for easy layering with other products.
Key Ingredients: 6 Peptides that boost skin elasticity, reduce post hyperpigmentation, control pores, renew skin, calm and alleviate skin, and improve the look of fine lines and wrinkles.
How to Use: After cleansing, apply 2-3 pumps of the Serum on your face. Layer on your favorite moisturizer for additional hydration. Best when used with the COSRX Snail 96 Essence and/or the COSRX Retinol 0.1 Cream.

Bestseller No. 2

Good Molecules Super Peptide Serum - Anti-aging Facial Serum with Peptides and Copper Tripeptides to Plump and Firm - Water-Based Skincare for Face

YOUTHFUL, HYDRATED, HEATHY-LOOKING SKIN: This anti-aging super serum is full of hydrating and firming ingredients to help your skin maintain its youthful glow! Embrace newfound confidence with the Good Molecules Super Peptide Serum.
TARGET FINE LINES, WRINKLES, AND PREMATURE AGING: Notice the difference in your skin! This serum works to reinvigorate, smooth, and plump, combatting the visible signs of aging and encouraging your skin's natural ability to produce collagen.
POTENT PEPTIDES FOR BRIGHT, FIRM SKIN: This formula is full of powerful peptides to rejuvenate your complexion! Copper tripeptides work to reinforce the look of firmness while acetyl hexapeptide-8 and acetyl octapeptide-3 help to reduce the appearance of fine lines and wrinkles.
PERFECT ADDITION TO YOUR BEAUTY REGIMEN: Apply a few drops in the morning and at night before oils, creams, and moisturizers. Let sit for 30 seconds before continuing with your routine.
GENTLE ENOUGH FOR ALL SKIN TYPES: Powerful enough to bring results and gentle enough for daily use; this serum is suitable for all skin types. Our serum has a pH of 6.09 and is vegan, gluten-free, fragrance-free, and was never tested on animals.

Bestseller No. 3

Advanced Clinicals 6X Concentrate Peptides Serum For Face | Hydrating + Firming Anti Wrinkle Collagen Peptide Moisturizer Face Oil W/Vitamin E For Wrinkles, Puffiness, & Uneven Skin Tone, 1.75 Fl Oz

IMMEDIATE RESULTS – Collagen Peptide Serum Instantly increase hydration to your skin by 88%! Within 1 week your skin will feel softer, smoother, and firmer. Within 1 month reduces crow’s feet and eye bags up to 37%!
6X PEPTIDE – Collagen Serum with 6 powerful peptides, is proven to diminish the look of premature aging and improve skin elasicity. Peptide Complex Serum is Enriched with 13 Organic antioxidant botanicals to fight free radicals and deliver a brightening boost.
EFFECTIVE EARTH ESSENTIALS – Dedicated to creating effective skin care products with natural ingredients, Advanced Clinicals formulates this 100% clean Peptide Serum in Chicago, using Quinoa, green tea, and blackberry extracts. Your skin will soak up an array of benefits with this serum, which is free from parabens and sulfates.
LIGHTWEIGHT FACE SERUM – Weightless hydrating serum refreshes dry, rough skin. Non-greasy formula, easily absorbs into your skin, giving your skin a youthful glow. Paraben-free and Mineral-oil free.
RELAX, PLUMP, & RESTORE – Non-Greasy Gentle PH Balanced Formula, Free From: Parabens, Drying Alcohols, PEGs, Sulfates, Dyes, & Talc. Manufactured in our FDA-Regulated & Inspected Laboratory in Chicago, USA. Dermatologist-Tested, Clinically-Tested, & Allergy-Tested Formula. Nourish, soothe, & protect your skin while reducing the pesky appearance of fine lines, sagging skin, & wrinkles.

Bestseller No. 4

Collagen Peptide Serum - Anti Aging Collagen Serum for Face, Skin Brightening, Reduces Fine Lines & Wrinkles, Heals and Repairs Skin, Microneedling Serum with Hyaluronic Acid (2 oz)

Skin-Firming: Our Peptide Complex Serum works by boosting collagen production, smoothing out wrinkles and giving your skin a smoother, softer feel.
Enjoy A More Blissful Routine: Ingredients such as witch hazel and jojoba provide a soothing finish to your skincare routine.
How It Works: Our Peptide Complex works by boosting your skin’s collagen production, helping to tighten and firm your skin while aloe and witch hazel work to stop irritation and keep your skin feeling soft and hydrated.
Packed With Botanicals: Ingredients such as aloe vera serve to hydrate the skin, while Witch Hazel soothes, reducing irritation.
Clean Beauty: Eva Naturals is dedicated to using high-quality botanicals, effective actives, and clean, science based synthetics in our products that are tried and tested to produce results. They are free of harmful parabens, sulfates and dyes.

Bestseller No. 5

Naturium Multi-Peptide Advanced Serum, Firming & Smoothing Face Serum for Fine Lines & Wrinkles with Advanced Multi-Peptide Blend, 1 oz

FIRMING & HYDRATING LIFT: Our Multi-Peptide Advanced face serum helps improve texture for a smoother complexion, supports firmer-looking skin, and plumps for a lifted effect
POWERFUL, ADVANCED MULTI-PEPTIDE BLEND: The encapsulated copper peptides and Argireline Amplified peptide work to improve texture and reduce the appearance of fine lines and wrinkles. Encapsulated ferulic acid and collagen help firm skin's appearance
MOST SKIN TYPES: Perfect for aging, blemish-prone, combination, dry, and sensitive skin, though a patch test is advised prior to use. Can be applied daily (AM + PM). Use 1-2 pea sized drops on clean skin followed by a moisturizer (and SPF during the day)
PROUDLY FORMULATED: All of our products are formulated to be pH level appropriate, Vegan, Cruelty Free, Paraben Free, Gluten Free, Skin Compatible, & Dermatologist Tested. Most of our skincare is Synthetic Fragrance Free
SKINCARE THAT WORKS: At Naturium, we are committed to providing affordable skincare essentials that use only ingredients directly benefiting the skin’s health, which support the integrity and effectiveness of our formulations

Bestseller No. 6

Cetaphil Healthy Renew Anti Aging Face Serum 1 Oz, Retinol Alternative Serum for Face with Niacinamide & Peptides, Skincare for Sensitive Skin with Vitamin B Complex, Fragrance Free

CETAPHIL HEALTHY RENEW FACE SERUM: Significantly improves skin's firmness, texture and tone in just 2 weeks
BOOSTS SKIN'S LUMINOSITY: Hydrates for 24 hours and reveals radiant, healthy-looking, glowing skin
RETINOL ALTERNATIVE FOR SENSITIVE SKIN: Purified peptides are an effective alternative to retinol as they are a gentler option for sensitive skin, don�t require typical adaptation time, and don�t increase sensitivity to sun, for anti-aging benefits with minimal skin disruption
RESPECTS SKIN'S NATURAL MOISTURE BARRIER: Vitamins B3 and B5 help to hydrate, soothe and restore the skin barrier, while botanical extracts target visible dullness and uneven skin tone
EFFECTIVE YET GENTLE ANTI-AGING: The fast-absorbing formula is hypoallergenic, fragrance free, paraben free and tested by dermatologists to be gentle enough for twice daily use on sensitive skin

Bestseller No. 7

Minimalist Multi Peptide Night Face Serum for Anti Aging with Collagen Boosting | Reduces Wrinkles | Hydrating Serum With 7% Matrixyl 3000 & 3% Bio-Placenta | For Women & Men | 1 Fl Oz / 30 ml

[ REDUCES FINE LINES & WRINKLES ]: A Multi-Peptide serum with a power of 7% Matrixyl 3000, a combo of 2 potent peptides that smoothen wrinkles & increase elasticity. Along with 3% Bio-Placenta that acts similar to human placenta with 5 peptides that promote cell growth and reduces wrinkles under eye by 46% and crow’s feet by 21% in 4 weeks.
[ BOOSTS COLLAGEN ]: The Minimalist Multi-peptide serum contains Bio-placenta, obtained from microbial fermentation, which helps in synthesizing various growth factors (very similar to human Placenta). The combination of five growth factors and other essential factors in Bio-placenta can have synergistic effects on the skin and helps in skin rejuvenation and cell revitalization. It also stimulates cell growth and promotes biosynthesis of collagen.
[ IMPROVES SKIN MOISTURIZATION ]: A hydrating lightweight serum that is proven to boost skin moisturization.
[ CLEAN & TRANSPARENT BEAUTY ]: This serum is (i) Fragrance-free (ii) Silicones-free (iii) Sulfates-free (iv) Parabens-free (v) Essential Oils-free and (vi) Dyes-free. Also, it is non-comedogenic and hypoallergenic. Formulated at pH 5.0 - 6.0 formulated with premium quality of Matrixyl 3000 by Croda, UK and Bio-placenta by Labio, Korea, leading global suppliers of skincare ingredients.
[ FOR ALL SKIN TYPES ]: This serum is suitable for all skin types viz. Dry, Oily, Normal, Sensitive, Combination

SaleBestseller No. 8

medicube PDRN Pink Peptide Serum, Pink glow serum, Peptide, Niacinamide, Hydrating & Moisturizing & Firming, Uneven Skin Tone, Korean Skincare | 1.01 fl.oz. (1.01 fl.oz., Rose PDRN (Vegan))

KOREAN GLASS GLOW SKIN: This pink glow serum targets dull skin and boosts elasticity, helping to prevent future breakouts while enhancing the skin's glow and resilience.
SALMON DNA PDRN: Salmon DNA PDRN is a form of DNA extracted from salmon. It stimulates skin renewal and repair, giving your skin a clearer, more luminous complexion. It promotes a more even skin tone and a natural glow by improving skin health.
KEY INGREDIENTS: Containing Rose PDRN, five types of peptide complex, niacinamide, adenosine, and Ocimum Sanctum (Holy Basil) leaf extract, this formula provides effective care for uneven skin tone and elasticity.
LONG LASTING HYDRATION: Strengthens the skin’s barrier function, enhancing its resistance to external aggressors and pollutants. It provides deep hydration and smooths skin texture.
MILD FORMULA LIGHT TEXTURE: The formula is mild and gentle for all skin types—gentle enough to be used daily. Dermatologist-tested, low-irritating, and free from gluten and artificial colors.

SaleBestseller No. 9

TruSkin Peptide Serum For Face – with Collagen Boosting Peptides, Amino Acids, Green Tea, Aloe and Vitamins B5 & E, 1 fl oz

POTENT SKIN NUTRITION: Infused with powerful Peptides, Silk Amino Acids and antioxidant-rich Green Tea, this nourishing pro collagen Peptide Serum nurtures tone, texture and tautness with potent daily nutrition.
BARRIER BOOSTING HYDRATION: Our fragrance-free Peptides serum for face is soaked with a nutrient-dense blend of Vitamins B5 & E, Aloe, and Botanical Hyaluronic Acid for a triple-shot of anti aging, barrier-boosting hydration.
POWER OF PEPTIDES: Peptides are short chains of amino acids that build skin’s vital proteins. Our Peptide Complex serum contains a collagen-friendly Peptide-Amino Acid Complex for robust, resilient skin.
CRUELTY FREE & MANUFACTURED IN THE USA: All TruSkin products are manufactured and bottled in the USA for guaranteed freshness—and they’re always Leaping Bunny-certified cruelty free.
THE TRUSKIN DIFFERENCE: If for any reason you decide this product isn't a fit for your skin, we're here for you. Each purposefully balanced medley of key antioxidants, super-nutrients and nourishing botanical actives enhances efficacy and delivers skin-friendly benefits, without added additives or fragrances. The expiration date is printed on the barcode sticker attached to the packaging.

Bestseller No. 10

Medik8 Liquid Peptides - Advanced Regenerating Multi Peptide Serum - Smooths Wrinkles and Fine Lines - Hydrating, Brightening, Plumping - 1.0 oz

REPAIR AND RENEW. Preserve and replenish your skin’s moisture while visibly smoothing texture. This regenerative, concentrated, crystal-clear peptide serum is designed to target signs of skin aging, like fine lines, dullness, and wrinkles.
REPLENISHING YOUR NATURAL GLOW. Achieve a smooth skin finish with this lightweight, tightening serum. Liquid Peptides is formulated with a 30 percent blend of essential multi-peptides, which work to revive the elasticity and bounce of mature skin.
INNOVATIVE PEPTIDE TECHNOLOGY. This powerful serum of vital peptides works to deliver an ageless complexion, softening the appearance of fine lines and wrinkles on the face. Skin is left visibly smooth and supple, with improved firmness overall.
RAPID HEALING HYDRATION HYDRATION. Skin will drink up this deep hydrating serum that sinks effortlessly into skin, infusing the complexion with moisture that works alongside peptides to smooth skin texture, reduce discoloration, and boost vibrance.
CUTTING-EDGE SKINCARE TECHNOLOGIES. Medik8 pioneers cutting-edge skincare technologies, with products are designed by our in-house formulation scientists and researchers dedicated to delivering the most well-researched, skin-healing results.

Related Posts