10 Best ointment for anal fissure (2025)

10 best ointments for anal fissure in 2025 offer effective relief and promote healing for this painful condition. These ointments typically contain soothing ingredients like lidocaine for pain relief, hydrocortisone to reduce inflammation, and natural extracts such as aloe vera and witch hazel for added comfort. Popular options include Preparation H, Anusol, and RectiCare, which are designed to ease discomfort and facilitate the healing process. Additionally, some formulations incorporate essential oils and vitamins to nourish the skin. Choosing the right ointment can significantly improve quality of life for those suffering from anal fissures.

SaleBestseller No. 1

Doctor Butler’s Hemorrhoid & Fissure Ointment – Hemorrhoid Treatment and Hemorrhoid Cream with Lidocaine and Phenylephrine HCI for Fast Acting Relief of Pain, Swelling, Discomfort, and Itching (1 oz.)

LEAVE THE PAIN BEHIND: Doctor Butler’s hemorrhoid ointment and anorectal lidocaine cream was developed by a Board Certified Proctologist to ensure our ingredients offer the best hemorrhoid treatment for women and men.
LIDOCAINE NUMBING CREAM: This hemorrhoid relief and fissure treatment formula works as a numbing cream for rapid relief from hemorrhoids. Our hemorrhoids cream also features Phenylephrine, a vasoconstrictor to help reduce swelling.
HEAL, SOOTHE and PROTECT: Discover instant relief with this paraben free hemorrhoidal cream that also features herbs, essential oils and minerals, and amino acids for added healing solutions. Aloe vera extract, ginseng extract and horse chestnut offer further benefits with skin protectant properties for external hemorrhoid care.*
LEADING HEMORRHOIDS TREATMENT: Join more than 200,000 satisfied new customers who purchased Doctor Butler’s hemorrhoid products for multi symptom relief over this year. Feel the relief of fissures and hemorrhoid pain, discomfort, burning, itching and swelling.*
MADE IN THE USA: Doctor Butler’s ointments, creams, and sprays are manufactured in the USA under rigorous quality controls to ensure the safe & effective use of all our products. We have also partnered with Leaping Bunny to maintain cruelty free standards across our brand.

Bestseller No. 2

Doctor Butler's Advanced Hemorrhoid & Fissure Ointment – Lidocaine Hemorrhoid Treatment and Fissure Treatment Extra Strength Formula, Heals and Provides Fast Pain and Itch Relief* (1.5 oz.)

LEAVE THE PAIN BEHIND: Doctor Butler’s hemorrhoid ointment was developed by a Board Certified Proctologist to ensure the use of the best ingredients for hemorrhoid relief and fissure treatment.
FIND FAST RELIEF: This lidocaine cream based formula works as a numbing cream to quickly alleviate your pain associated with hemorrhoids.* We created a hemorrhoids cream for both pain and itch relief that works quickly and efficiently.
HEAL AND SOOTHE: This hemorrhoid cream is made with lidocaine to numb and soothe your skin, along with its unique formula of organic herbs, essential oils, minerals an amino acid, bringing you added healing solutions. It’s also made paraben-free!
LONGER-LASTING PROTECTION: The Advanced formula features lidocaine ointment to protect inflamed tissue with glycerin to reduce friction and pain, for rapid relief and longer-lasting coverage. Added ingredients like ginseng extract and horse chestnut offer you a natural skin protectant and anti-inflammatory properties.*
MADE IN THE USA: Doctor Butler’s products are manufactured in the USA and are produced in our facility. Rigorous quality control of ingredients is done and a safety seal is added to prove the SAFE & EFFECTIVE use of our products. We have also partnered with Leaping Bunny to maintain cruelty free standards.

SaleBestseller No. 3

Hemorrhoid Cream, Hemorrhoid & Fissure Treatment Ointment Extra Strength, Relief Anal Pain, Itching, Bleeding, Swelling, Discomfort, Natural Herbs Fast Acting Ingredients, Contains Vitamin E

Highly Effective Treatments: Hemorrhoid treatment cream provides immediate relief of pain, itching, burning, swelling, fissure, bleeding, discomfort from hemorrhoids & fissures, while effectively shrinking the hemorrhoid tissues and soothing the swelling fissures
Fast Heal, Soothe & Protect: Hemorrhoid cream contains camphor, petrolatum, sophora flavescens root, stellera chamaejasme whole, cnidium monnieri fruit, menthol which will give you more faster healing and pain relief. Our hemorrhoid ointment can also form a natural protective layer on affected areas to protect your irritated & inflamed tissues
Rapid Restore: Maximum strength hemorrhoidal cream that takes effect Immediate results. It is suitable for the elderly, obese, prone to constipation or diarrhoea, sit for long periods of time or have an unhealthy lifestyle. After applying our hemorrhoid & fissure ointment, you can back to normal quickly
Easy To Use & Gentle Properties: Hemorrhoid treatment cream boasts multiple applicators. Can be applied with the provided applicator, or add the cream to wipes, or use finger for external and internal hemorrhoids. With a slight refreshing medicine scent, our gentle hemorrhoid ointment can stay on the surface of hemorrhoids and anal fissures for continuous soothing
Quality Guarantee: Within 365 days from the date of purchase, we will ongoing provide replacement products or refund services. If you have any questions or demand about iShanCare hemorrhoid cream, please feel free to contact us. Note: The application of internal hemorrhoids also falls under the category of “external use only”

SaleBestseller No. 4

Calmoseptine Ointment Tube 4 Ounce (Pack of 2)

2 pack
4 oz. tube
temporarily relieves discomfort and itching. Provides a multiple purpose moisture barrier.

Bestseller No. 5

Forces of Nature Organic Fissure Control for Hemorrhoid Treatment, 0.37 Fl Oz, Soothe & Relieve Burning, Throbbing, Stinging, Itchy, Bleeding Tissue Caused by Fissures or Hemorrhoids, Non GMO

MULTI ACTION CARE: Ease the discomfort of anal fissures, cracked skin and scrapes with our gentle fissure care. Formulated to help soothe and relieve burning, throbbing, stinging, itching, bleeding tissue caused by fissures or hemorrhoids
HOMEOPATHIC & NATURAL MEDICINE: Our natural anal fissure relief combines Witch Hazel and Marigold with German chamomile, Lavandula and Helichrysum soothing organic essential oils, providing effective relief from discomfort
HELPS REPAIR AND HEAL: Our fissure treatment offers the dual benefits of relief and rejuvenation. The vegan-friendly formula aids in soothing irritation, and supports a healing process that helps treat and repair damaged skin
FAST-ABSORBING FORMULA: Our natural fissure care offers fast-acting relief for pain associated with anal fissures, especially during bowel movements. Dab 2-3 drops of oil to the treatment area 2-4 times per day. Apply daily until problem is gone
WHY WE'RE DIFFERENT: We strive to provide safe, organic remedies for families in search of a healthier solution to their health needs.

Bestseller No. 6

LMNOOP Perianal Repair Ointment: Treatments for Anal Fistula, Anal Fissure, Perianal Abscess, Rapid Relief from Pain, Burning, Itching, Swelling, Bleeding, and Discomfort by Jock Itch or Hemorrhoids

MULTI-FUNCTION: LMNOOP perianal repair ointment focuses on anal fistula, perianal abscess, and fissures as comfortably. Effective treatment anal pain, anus fissure, perianal abscess, anal swelling, anal fistula surgery wounds, postpartum wounds, shaving wounds, privates discomfort, infections, ulcers, sores, and folliculitis.
WORKS FAST: Quick relief for pain, burning, itching, swelling, bleeding, and discomfort from anal fissures, and perianal abscesses. Temporarily protects the inflamed, irritated anorectal surface to help make bowel movements less painful. Quickly enable the skin condition of cracking, chafing, bruises, rashes, infections and wounds, and recovery discomfort for perianal, groin, and inner thighs areas.
NATURAL INGREDIENTS: Blend of all-natural herbals that work wonders - organic sesame essential oil, bees wax, lavender, cactus extract, propolis, etc, deep moisturizing formula that is non-irritating, soothing, gentle, and safe.
GET BACK TO NORMAL LIFE QUICKLY: Suitable for people who are obese, pregnant, prone to constipation, and diarrhea, need to sit for a long time, and often live an unhealthy diet, to help you quickly return to normal life.
EASY to USE： You can add the ointment to wipes, or fingers for the affected area. Suppose the anus is particularly dry and the fingers are difficult to enter. You can apply the ointment to the outside of the fingers, and the perianal area, and then use the fingers to enter the anus.

Bestseller No. 7

Ebanel 4% Lidocaine Hemorrhoid Treatment Ointment with Phenylephrine, Hydrocortisone, Vitamins B6, D3, E, Zinc Oxide, External and Internal Hemorrhoids Treatment Burn Itch Pain Relief Anal Cream

FSA HSA Eligible OTC Hemorrhoid Treatment - this clinically proven hemorrhoid ointment, featuring active ingredients of Lidocaine 4% and Phenylephrine HCl 0.25%, effectively numbs local and anorectal pain, anal itching, burning, soreness, and discomfort
Hemorrhoid Shrinking Treatment Reduces Swelling and Inflammation - enhanced with Hydrocortisone, Vitamin B6, Ginseng Root, and Chamomile, this anal numbing ointment hemorrhoidal treatment temporarily shrinks hemorrhoidal tissue, reduces irritation, bleeding, and anorectal disorders, alleviates inflamed anal fissures, rectum, and pregnancy piles
Repairs and Heals Skin Barrier associated with Hemorrhoids - formulated with anti-inflammatory Vitamin D3, Zinc Oxide, Cholesterol, Phospholipids, and Pomegranate, this hemorrhoid relief anal fissure ointment forms a protective barrier on inflamed, torn, and damaged tissue, calms and soothes the hemorrhoids and swollen fissures
Moisturizes & Lubricates with Skin Protectants - infused with Vitamin E, Lecithin, Safflower Oil, Mineral Oil, and Petrolatum, this hemorrhoidal lidocaine ointment lubricates and coats sensitive passageways, protecting irritated tissue. The multi-symptom thick formula stays in place, providing long-lasting relief
Made in USA in an FDA Registered Facility - clinically proven effective and safe for all skin types, this hemorrhoid cream with lidocaine is cruelty-free, cGMP certified, hypoallergenic, and non-comedogenic. Comes with 3 applicators for convenience

Bestseller No. 8

Intense Hemorrhoid Treatment 100% Natural Hemorrhoid Cream & Fissure Ointment Control Organic Lavender Arnica Witch Hazel Fast Healing Maximum Strength, Best with Thena Sitz Bath Soak for Women Men

Apply with peace of mind - natural, gentle healing starts here, formulated with the finest skin-loving, wellness-boosting, good for skin good for well-being ingredients, plant based healing properties and pure therapeutic grade essential oils that provide max sooth & comfort without side effect;
Organic st. john’s wort, witch hazel, yarrow, white oak bark, comfrey, arnica, plantain known for providing intensive preventive care and protecting against flare-up;
Accelerates the progress, for pregnant or postpartum moms during pregnancy, before and after labor delivery, a little goes a long way;
Works best with Thena Sitz Bath Soak, gentle & fasting acting all natural postpartum essentials and complete care kit

Bestseller No. 9

Bloop Maximum Strength Advanced Anorectal Fissure Recovery - Brazilian Superfruit & Plant-Based Oils | Effective for Acute, Chronic Fissures & Pain | Contains 5% Lidocaine

ANORECTAL FISSURE RELIEF: Bloop Anorectal Fissure Healing Cream is a powerful blend of Amazon Superfruits and 5% Lidocaine that provides swift relief from the discomfort of anal fissures. It eases pain and expedites the healing process, helping you get back to feeling your best.
PREVENT RECURRENCE: Our unique formula goes beyond healing; it protects against new fissures. Harnessing the benefits of Brazilian Superfruits and Plant Oils ensures your comfort remains uninterrupted, giving you peace of mind.
INSTANT SOOTHING: Infused with 5% Lidocaine, our cream offers immediate relief from the burning and itching associated with rectal fissures. You can trust Bloop for quick and effective pain relief, allowing you to focus on your healing journey.
FAST-ABSORBING: Bloop AnalFissure Healing Cream quickly penetrates the skin without leaving a sticky residue on your undergarments, leaving your skin silky and soft.
NATURAL HEALING: Bloop's Cream taps into the natural healing powers of Açai and Pracaxi oils. Açai berries are rich in antioxidants, promoting skin elasticity and hydration, while Pracaxi oil is a source of essential fatty acids that support overall skin health.

Bestseller No. 10

LMNOOP® Hemorrhoid Treatment Ointment, Maximum Strength Treatment & Fast Relief for Pain, Itching, Burning, Swelling, Fissure, Bleeding, Discomfort, Long-Lasting Internal & External Hemorrhoid Cream

【HIGH EFFICIENT】LMNOOP hemorrhoid treatment cream has been proven to be effective in the treatment of both internal and external hemorrhoids. Meanwhile, it can relieve & repair perianal wounds quickly.
【RAPID RELIEF】With mild, delicate properties, LMNOOP hemorrhoid cream is easy to absorb and delivers rapid relief for pain, bleeding, burning, itching and swelling from hemorrhoids and anal fissures.
【NATURAL INGREDIENTS】LMNOOP hemorrhoid ointment boasts selected natural herbal ingredients that provides maximum strength soothing relief without side effects.
【PROTECT YOUR SKIN】LMNOOP hemorrhoidal cream contains a variety of organic ingredients, among which, aloe vera extract has anti-inflammatory properties to fight infection and protect your skin.
【SATISFACTION GUARANTEE】LMNOOP hemorrhoid & fissure ointment comes with a 365-day money-back guarantee from the date of purchase. If you have any questions, please feel free to contact us.

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