10 Best muscle pain relief cream (2025)

Muscle pain relief cream options in 2025 have evolved significantly, offering effective solutions for discomfort and soreness. Top contenders include Biofreeze, known for its cooling effect, and Tiger Balm, which combines herbal ingredients for deep relief. Other notable mentions are Voltaren Gel, a powerful anti-inflammatory, and Sombra Warm Therapy, perfect for soothing tight muscles. Additionally, Penetrex and CBD-infused creams have gained popularity for their natural pain-relieving properties. For those seeking a more holistic approach, Arnica-based creams provide gentle relief, while Icy Hot remains a classic choice. These creams cater to various preferences, ensuring effective muscle pain management.

SaleBestseller No. 1

Boiron Arnicare Gel for Soothing Relief of Joint Pain, Muscle Pain, Muscle Soreness, and Swelling from Bruises or Injury - Non-greasy and Fragrance-Free - 2.6 oz

ARNICA FOR PAIN: This homeopathic medicine helps temporarily relieve muscle pain & stiffness due to minor injuries, overexertion & falls. Also great for pain, swelling, & discoloration from bruises.
TOPICAL PAIN RELIEF: Our non-greasy, water-based formula absorbs quickly & is unscented & paraben-free. This cooling gel is great for relief following an injury, intense workout, or general overexertion.
PLANT-BASED ACTIVE INGREDIENT: The Arnica montana plant is a natural pain reliever. This popular homeopathic medicine temporarily relieves muscle pain & stiffness without unwanted drowsiness.Fluoride-Free
HOMEOPATHIC MEDICINE uses highly diluted biological, botanical, or mineral substances to relieve symptoms. Our tablets, pellets, & topical treatments work with your body without the risk of contraindications, or known drug interactions.
THE BOIRON PROMISE: We believe there’s more than one way to feel better. Since 1932, we have been committed to providing quality medicines. As a world leader in homeopathy, our passion is your health. Our promise is your satisfaction.

Bestseller No. 2

Penetrex Joint & Muscle Therapy – Soothing Comfort for Back, Neck, Hands, Feet – Premium Whole Body Rub with Arnica, Vitamin B6 MSM & Boswellia – Non-Greasy 2oz Cream

Effective for Joints and Muscles: Penetrex is the whole-body therapy cream you’ve been waiting for; trusted by over 2 million sufferers; offers a different kind of comfort
The Penetrex Difference: Our proprietary blend of natural ingredients leverages the power of arnica, vitamin B6 and MSM to penetrate deeply for joint and muscle discomfort at the source
Premium Experience: Penetrex is a non-greasy, non-sticky, non-staining, paraben-free, cruelty-free and vegan soothing cream without the burn, freeze or strong odor of other products
See Why So Many People Trust Penetrex: Penetrex allows you to get back to doing the things you love
Directions: Apply to back, neck, knee, hand, foot, and more; Penetrex can be used on its own or with other therapies such as heating pads, ice packs, massagers and supplements; apply 3-4 times per day for 7-10 days, then apply as needed

Bestseller No. 3

Bengay Ultra Strength Topical Pain Relief Cream, Non-Greasy Topical Analgesic for Minor Arthritis, Muscle, Joint, and Back Pain, Camphor, Menthol & Methyl Salicylate, 4 oz

4-ounce tube of non-greasy Bengay Ultra Strength Topical Pain Relief Cream to ease backaches, minor arthritis, muscle, and joint pain
Topical analgesic contains three pain-relieving ingredients—camphor, menthol, and methyl salicylate, for ultra-strong relief in a non-greasy cream.
Pain relief cream penetrates deeply for back and arthritis pain relief and soothing of other minor aches, sprains and bruises
Bengay is a physician-recommended OTC topical analgesic. Contains more pain-relieving ingredients than any other Bengay product
Topical pain relief analgesic comes in a convenient tube for portable & on-the-go relief from aches, minor arthritis, joint, and back pain

SaleBestseller No. 4

Biofreeze Pain Relief Gel, Arthritis Pain Reliver, Knee & Lower Back Pain Relief, Sore Muscle Relief, Neck Pain Relief, Pharmacist Recommended, FSA Eligible, 3 FL OZ Biofreeze Menthol Gel

#1 Clinically Recommended Menthol Topical Pain Relief Brand
This 3 fl oz gel tube is one of the most popular formats, well-suited for application on small and large muscle areas
Biofreeze is a clinically recommended brand; trusted by pharmacists, physical therapists, chiropractors, massage therapists, podiatrists, and athletic trainers
Product is not tested on animals, made with USP grade menthol, and free of NSAIDs
Product is not tested on animals, made with USP grade menthol, and free of NSAIDs

Bestseller No. 5

Icy Hot Max Strength Pain Relief Cream with Lidocaine Plus Menthol, 1.75 Ounces

Includes one (1) 1.75-oz. tube of Icy Hot Max Strength Pain Relief Cream With Lidocaine Plus Menthol
Icy Hot Lidocaine Cream desensitizes aggravated nerves to temporarily relieve minor pains associated with foot pain, back pain, muscle pain, knee pain and arthritis pain
This pain cream penetrates to the nerves for quick relief in minutes that lasts for hours
Apply non-greasy Icy Hot Pain Relieving Cream With Lidocaine Plus Menthol to the affected area every 6-8 hours; do not exceed 3 applications in a 24-hour period
Icy Hot is the number-one topical pain relief brand* *among OTC topical analgesics

SaleBestseller No. 6

Tiger Balm Extra Strength Pain Relieving Ointment, 0.63 Ounce (18 g)

Tiger Balm Extra Strength Ointment provides fast-acting and long-lasting relief for joint and arthritis pain
Effective relief for most symptoms of bodily aches and pains including , rheumatism, arthritic pains, and muscle strains and sprains
The cassia oil (cinnamon) in Tiger Balm Extra provides a soothing aroma
The herbal blend helps to relieve joint and muscle pain and soothe tired muscles

Bestseller No. 7

Advil Targeted Relief Pain Relieving Cream, Up to 8 Hours of Powerful Relief of Minor Arthritis Pain, Joint Pain, Lower Back Pain and Muscle Pain - 2.3 oz

One 2.3 oz Tube of Advil Targeted Relief Pain Relieving Cream - The only topical pain reliever with 4 powerful pain-fighting ingredients (1)
Provides a warming & cooling sensation on contact and lasts up to 8 hours (1)
Designed to quickly tackle pain four ways: targets, penetrates, blocks, and relieves
Fast and powerful relief for minor arthritis pain, muscle, joint and back pain - the perfect addition to your college dorm room essentials
Doesn't leave your skin feeling dry or greasy and easily glides onto skin, ensuring comfort with every use

SaleBestseller No. 8

Aspercreme Lidocaine Pain Relief Cream Soothes Aggravated Nerves, Numbing Topical Analgesic with Max-Strength 4% Lidocaine & Moisturizing Aloe, 4.3 Oz.

Contains one (1) 4.3-oz. tube of Aspercreme Pain Relief Cream With Max-Strength Lidocaine & Moisturizing Aloe
Fast-Acting Relief: Experience rapid and lasting pain relief with max-strength 4% lidocaine topical numbing cream, designed to target nerves and numb away pain
Non-greasy Formula: Fragrance-free Aspercreme moisturizes and relieves without greasy residue or strong odor
Maximum-Strength Lidocaine: OTC Aspercreme offers the maximum-strength lidocaine pain relief available without a prescription and is FSA/HSA eligible
Travel-Size: Take your pain relief solution on the go in a compact and portable tube

Bestseller No. 9

Biofreeze Pain Relief Cream, Knee & Lower Back Pain Relief, Sore Muscle Relief, Neck Pain Relief, Shoulder Pain Relief, Muscle Recovery, FSA Eligible, 3 OZ Biofreeze Menthol Cream

#1 Clinically Recommended Menthol Topical Pain Relief Brand
Biofreeze Menthol Pain Relieving Cream is non-greasy with natural moisturizers and penetrates for pain relief
Fast acting, cooling menthol formula delivers and penetrating pain relief for minor aches and pains of muscles and joints associated with simple backache, arthritis, strains, bruises, and sprains
This 3 oz. cream jar comes in TSA-approved sizing for hassle-free travel or on the go pain relief
Biofreeze is a clinically recommended brand; trusted by pharmacists, physical therapists, chiropractors, massage therapists, podiatrists, and athletic trainers

Bestseller No. 10

Sombra Original Warm Therapy Gel Cool to Warm Relief for Arthritis and Chronic Pain Pre-Workout Muscle Rub Vegan Formula Free of Artificial Fragrances, Dyes, NSAIDs, Wax, Petroleum, Alcohol - 8oz Jar

Absorbs quickly with a refreshing orange scent.
Alcohol free, non-greasy, non-staining.
Unique warming and cooling ingredients.
Animal Free. Made in the USA
Relieves minor aches and pains of muscles and joints associated with arthritis and simple backaches

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