10 Best methylated multivitamin (2025)

Methylated multivitamins are gaining popularity for their enhanced bioavailability and effectiveness in supporting overall health. In 2025, the 10 best methylated multivitamins stand out for their superior formulations, which include essential nutrients like methylcobalamin, methylfolate, and other bioactive compounds. These multivitamins cater to various dietary needs, ensuring optimal absorption for individuals with MTHFR gene mutations or those seeking to boost their energy levels and cognitive function. With brands focusing on quality ingredients and rigorous testing, consumers can confidently choose from these top-rated options to enhance their wellness journey.

Bestseller No. 1

10X Health Optimize Methylated Multivitamin for Men & Women - 34 in 1 Formula with 800 mcg of Vitamin B12, Vitamin E, 5-MTHF, B Complex, NAC, Magnesium & Zinc Multivitamins - 90 Capsules

Targeted Nutritional Support: 10x Optimize methylated multivitamins offer the ultimate multivitamin and mineral formula to address genetic deficits in your methylation pathway. This impacts your overall wellness and supports optimal health.
Essential Methylated Nutrients: This includes crucial methylated vitamins like 5-MTHF (methylated folic acid), methylated B12, riboflavin (B2), and pyridoxine (B6). This multivitamin-methylated formula supports your body's natural methylation processes.
Vital Minerals for Balance: Formulated with optimized minerals such as magnesium and zinc, 10X Optimize multivitamins for women and men help to maintain essential mineral balance and support the immune system, energy production, and cognitive function.
Additional Methylation Support: Contains NAC (N-acetyl L-cysteine), a powerful amino acid known for its excellent support of the methylation pathway. NAC helps boost your body's ability to boost antioxidant levels and promote cellular health.
Quality and Safety Focused: The 10X Optimize methylated multivitamin from 10X Health System is proudly made in the USA using premium, carefully sourced ingredients. Each batch undergoes rigorous quality and purity testing, ensuring your wellness.

SaleBestseller No. 2

Methylated Multivitamin (Methylated and Activated Vitamins Only - Methylated B Complex with Trimethylglycine (TMG) and Methylfolate)(Non-GMO, Gluten Free MTHFR Supplement) 120 Capsules by Double Wood

Only Methylated / Activated forms of Vitamins - Double Wood's Methylated Multivitamin only contains methylated / activated forms of vitamins that are already usable by the body and do not need to be further converted in order to be bioavailable / usable
Methylated B Complex- Double Wood's Methylated Multivitamin contains the Methylated / Activated Coenzyme form of Vitamin B2 (R-5-P), Vitamin B6 (P-5P) and Vitamin B12 (Methylcoblamin and Dibencozide)(Methyl B12)
Six Total Methylated Vitamins - Along with the Methylated B Complex we include trimethylglycine and calcium L-5-methyltetrahydrofolate (mthfr multivitamin) to help support healthy folic acid levels and control homocysteine levels in the body. It is important to use methylated folic acid since standard folic acid is inert in the body and cannot be processed further by many people
Can be Combined with a Normal Multivitamin - Double Wood's Methylated Multivitamin can be combined with a regular multivitamin for those looking to also supplement with inactive vitamins or vitamins such as magnesium and Vitamin D
Manufactured in the USA from Globally Sourced Ingredients, Non-GMO, Gluten Free - Double Wood's Methylated Multivitamin is Manufactured in the USA from Globally Sourced Ingredients, Non-GMO, and Gluten Free

Bestseller No. 3

envitamin Methylated Multivitamin Multimineral Complex L Methylfolate

Methylated Multivitamin Complex By envitamin with L Methylfolate
Methylated B12, 5-MTHF, Inositol, & Lycopene
Contains the micronutrients you need for your body

Bestseller No. 4

Methyl Multi Without Iron Methylated Multivitamin for Men & Women, 60-Day Supply | Methyl B12 & Methylfolate (5-MTHF) for MTHFR Support | Pharma Grade Multivitamin & Multimineral For Health, 120 Caps

𝐄𝐋𝐄𝐕𝐀𝐓𝐄 𝐓𝐎𝐓𝐀𝐋 𝐖𝐄𝐋𝐋𝐍𝐄𝐒𝐒: Discussed on The Joe Rogan Experience with Gary Brecka, Methyl Multi without Iron is a vegan-friendly, hypoallergenic, and meticulously-researched multivitamin and multimineral supplement made from high-quality ingredients with zero fillers. Our comprehensive formulation promotes healthy cognitive function and supports antioxidant protection and detoxication. Methyl Multi is the ultimate multivitamin to support total-body wellness and optimum vitality.
𝐎𝐏𝐓𝐈𝐌𝐀𝐋 𝐀𝐁𝐒𝐎𝐑𝐏𝐓𝐈𝐎𝐍: When supplementing, absorption is key! Methyl Multi without Iron is formulated with Quatrefolic Folate (5-MTHF), Albion TRAACS mineral chelates, and other micronutrients in their pre-methylated and coenzyme forms for optimal absorption and bioavailability, all together in DRcaps acid resistant vegetable capsules.
𝐂𝐎𝐌𝐏𝐋𝐄𝐓𝐄 𝐌𝐓𝐇𝐅𝐑 𝐒𝐔𝐏𝐏𝐎𝐑𝐓: Millions of Americans have MTHFR and/or COMT mutations, making it difficult for their bodies to process key vitamins like B12 and Folate. Methyl Multi without Iron contains pre-methylated forms of B12 and Folate for increased bioavailability, which can help to support healthy metabolism, energy release from food, detoxification, and nervous system function.
𝐍𝐄𝐖 𝐓𝐎 𝐌𝐄𝐓𝐇𝐘𝐋𝐀𝐓𝐈𝐎𝐍? For those extremely sensitive or new to methylated vitamins, we recommend gradually increasing the amount you are taking so your body can adapt. A small percentage of customers can experience a temporary detoxification / Herxheimer response. Symptoms may include: headache, lethargy, skin rash / hives, respiratory symptoms (cough, sore throat). These are temporary and a sign that the supplement is working. However if your body detoxes too quickly at one time it can overload your detox pathways! It’s imperative to lower the amount you are taking for a few days and work your way up slowly to the full dose “LOW & SLOW”
𝐍𝐎 𝐀𝐑𝐓𝐈𝐅𝐈𝐂𝐈𝐀𝐋 𝐈𝐍𝐆𝐑𝐄𝐃𝐈𝐄𝐍𝐓𝐒: Pure TheraPro Rx Methyl Multi without Iron contain no fillers such as rice flour, cornstarch, or wood pulp fibers. Our manufacturing facility adheres to strict NSF/cGMP guidelines. Consumer safety and satisfaction are our highest priority, which is why our products undergo rigorous third-party testing and screening to ensure product purity and potency.

Bestseller No. 5

Methylated Men's Multivitamin, MTHFR Supplement with Active B-Vitamins, High Strength 2 a Day Multivitamin for Sustained Release, Added Lycopene, Clean Label, Non-GMO & Vegan 60 Tablets, by Igennus

METHYLATED & ACTIVE FORMS - each nutrient form has been carefully selected to optimize the journey from supplement to cell. Includes methylated B-vitamins, chelated minerals and gentle zinc*
SLOW-RELEASE FORMULA: blood nutrient levels are optimized with bioactive vitamin forms & slow-release formula. Take 1 tablet twice per day as a split dose
MULTIVITAMIN FOR MEN: 22 high-potency nutrients including bioactive B-complex, chelated minerals and antioxidant complex enhanced with lycopene; iron-free
MORE OF WHAT YOU NEED, LESS OF WHAT YOU DON'T - our nutritionists have formulated a comprehensive multivitamin for men, topping up nutrients often lacking in everyday diets, without unnecessary extras*
PURE & CLEAN: lab-verified ingredients; UK GMP manufactured; vegan; no silicon dioxide or magnesium stearate; fully recyclable packaging; easy-to-swallow oval tablets

SaleBestseller No. 6

Methylated Women's Multivitamin, Methylated Folate for MTHFR, Clean Label & Vegan, with Iron, Non-GMO, Halal, Sustained Release, 60 Tablets, by Igennus

METHYLATED & ACTIVE FORMS - each nutrient form has been carefully selected to optimize the journey from supplement to cell. Includes methylated B-vitamins, chelated minerals, gentle iron and zinc*
PURE & CLEAN vegan, non-GMO, hypoallergenic & lab-verified ingredients with no unpleasant fillers (silicon dioxide, magnesium stearate or titanium dioxide). GMP manufactured in the UK
HIGH POTENCY we have boosted levels of iron, B-vitamins, vitamin D and zinc in ratios that work in balance with the body. Provides enhanced support for energy, immunity, hormone balance and mood. Supplementing with iron may not be suitable for postmenopausal women*
MORE OF WHAT YOU NEED, LESS OF WHAT YOU DON'T - our nutritionists have formulated a comprehensive multivitamin for women of menstruating age, topping up nutrients often lacking in everyday diets, without unnecessary extras*
ALL-DAY COVERAGE this high-absorption formula is enhanced with sustained release delivery, optimizing blood nutrient levels for maximum health benefits and peace of mind. Take two, small tablets daily*

Bestseller No. 7

Power By Naturals Methyl Multi One - Vegan Methylated Multivitamin for Men & Women with Methylfolate & Methyl B12 for MTHFR Maintenance, 60 Capsules, 2 Month Supply, USA-Made, Gluten-Free

EXPERIENCE THE POWER OF METHYL MULTI ONE: Our high-potency methylated multivitamin is perfect for both men and women, offering a comprehensive blend of 27 vitamins and minerals, including methylated b complex, ADK, C and E in highly bioavailable forms. Packed with CoQ10, 5-MTHF, and ALA for antioxidant support, this formula is designed for easy absorption. It's your balanced, convenient, and economical one-a-day solution for adults.
UNLOCK ESSENTIAL MTHFR SUPPORT: Our methylated multivitamin is here to elevate your mineral intake, especially if you have gene variants. With body-ready active forms like bioactive Folate, Methyl B12/B6, and enzymatic cofactors, it optimizes methylation, promoting overall well-being and balance.
ALL -IN-ONE DAILY VEGAN MULTIVITAMIN: Get complete daily nutrition in just one capsule. Our convenient, balanced one-a-day multivitamin supports overall wellness, including bone, heart, eye, and metabolic health. Packed with ADK, methyl folate, active B12, CoQ10, and essential vitamins/minerals, including amino acids and B vitamins, it ensures your body gets everything it needs every day.
NATURAL VARIATIONS EXPLAINED: Some bioactive vitamins may have a noticeable scent due to oxidation, and you might see product speckles from chelated minerals that aid absorption—both are normal occurrences. We avoid artificial additives to preserve the product's natural characteristics. Store it in a sealed, dry space at a cool room temperature or refrigerate to minimize scent due to oxidation.
USA-MADE EXCELLENCE: Our USA-made products feature premium ingredients, crafted in a top-tier NSF/GMP facility for safety. Our multivitamin is gluten-free, GMO-free, Vegan-Friendly, and additive-free, showing our dedication to your well-being and smart nutrition choices. Experience the confidence that comes with American-made quality.

Bestseller No. 8

Inessa Methylated Multivitamin for Men - Advanced Natural Daily Mens Multivitamins with CoQ10 100mg, Vitamins D3, K2, A, B Complex Vitamins, Folic Acid & Zinc - 60 Vegan Tablets for Men & Women

[Feel Like You, But Better] You want to thrive, not just survive. You want best, not just better, health. So meet the cutting-edge multivitamin supplement designed with your optimal wellness in mind. This magical multivitamin with K2 and vitamin D3 is productivity powerhouse that keeps you feeling fresh and focused, all-day-long.
[Daily Wellness, Simplified] - Why take multiple supplements to get everything you need? This one-a-day wonder has 25 ingredients in highly bioavailable doses crammed into every dose. It’s one of the only multivitamins that works like an antioxidant complex, B-complex, CoQ10, vitamin D3 and vitamin K2 supplement in one.
[Vegan Society Approved] Eating clean? We hear you. This women's and men’s vegan multivitamin is also allergen, gluten and dairy free. But don’t just take our word for it. We batch test our multivitamin supplement for purity and it contains no unnecessary additives, chemicals, flavorings or color.
[Fights Fatigue] Micronutrient deficiencies can impact your vitality, and even healthy diets may not give you everything you need for boundless energy. But with relevant doses of CoQ10, B-complex vitamins, D3, iodine and more, this women's and men’s multivitamin will put the natural spring back into your step.
[Nature's Nourishment] - Embrace a natural approach to wellness with our gluten-free, vegan multivitamin. Crafted for modern men like you, it champions your dietary choices while enriching your health journey. Make every day a step toward a healthier, happier you!

Bestseller No. 9

Methylated Multivitamin for Women Gummies with Calcium, Magnesium, Zinc, Vitamin A, C, D3, E, K2, B Complex, Folate, Biotin - Multi Vitamins & Minerals for Energy, Immune Support,and Strengthen Bone

MANY ESSENTIAL INGREDIENTS: Simplify your wellness routine with Women's Multivitamin Gummy. Packed with 22 essential vitamins and minerals, including Vitamin A, B, C, E, D3,K2,Calcium, Magnesium, Zinc, and Iodine, it also boasts critical nutrients like Omega-3, Algae Oil, EPA, DHA, Lutein, and natural extracts from Black Elderberry, Turmeric, Echinacea, and Ginger Root.
Strengthen Bone, Teeth & Muscle: Calcium from red algae is more easily recognized and absorbed by the body. Womens vitamins multivitamin is expertly formulated with vitamin D3 (from VEGAN lichen) for better absorption, Vitamin K2 as MK7 to direct calcium to bones (where you need it most). Ca + D3 + K2 work together to help promote strong and healthy bones, joints, teeth & immune.
Multivitamins with Natural Algae Oil, Omega-3 DHA & EPA, and Lutein: Elevate your cognitive abilities and improve attention with our powerful Women's gummies, which also boosts visual acuity. Featuring Omega-3 (DHA 200mg & EPA 100mg), Algae Oil 500mg, and Lutein 10mg. Whether you're conquering the boardroom or devouring novels, our formula supports sharp thinking and crystal-clear vision.
OPTIMAL HEALTH WITH HIGH ABSORPTION: The multivitamin women's 100% of your daily nutritional needs, scientifically designed to promote overall health balance. It contains vitamins and minerals, including Vitamins A, C, D, E, B2, B3, B6, B7, B12 and Folate, as well as Calcium, Magnesium, multivitamin women's gummies utilize advanced filling technology to securely encapsulate the nutrients, ensuring superior absorption and efficacy.
VEGAN PEACH FLAVOR GUMMIES: SciNutr women's multivitamin gummies are made with all-natural, organic, non-GMO ingredients. They are sugar-free, gluten-free, and contain no artificial flavors or preservatives, making them a healthy and convenient choice. The multivitamin gummies are easy to chew and swallow, simply enjoy two delicious gummies per day to cover all your nutritional needs.

Bestseller No. 10

Methylated Multivitamin for Men and Women | Methyl B12, Methylfolate, 5-MTHF, Vegan, Iron-Free, Energy & Immune Support | 60 Vegetable Capsules | Manufactured in The USA

Advanced methylation support: Our methylated multivitamin features active methylated folate (5-MTHF) and methylcobalamin (B12) to support healthy methylation and homocysteine levels, promoting optimal cellular function and energy production.
Methylated multivitamins: Our powerful methylated multivitamin complex contains seven essential B vitamins, including methylcobalamin, biotin, pyridoxine, pantothenic acid, niacin, riboflavin, and thiamine. These vitamins are vital for energy production, brain health, and overall well-being, making it an ideal methylated multivitamin for women, and men.
Convenient daily dose: Each easy-to-swallow vegetable capsule delivers 27 natural vitamins and micronutrients, including zinc, selenium, choline, and potent antioxidants like CoQ10, alpha-lipoic acid, and lutein. These supplements provide essential nutrients in a single daily serving.
Natural variation in smell and color: Due to the pureness of our methylated multivitamin and the presence of active ingredients like B12 and folate, a strong smell and occasional color change due to oxygen may occur. These are normal and natural aspects of high-quality methylated vitamins and do not compromise the effectiveness or quality of the supplements.
Quality you can trust: Proudly made in the USA, our pure methylated multivitamin formula is tested for purity and potency. Free from gluten, lactose, GMOs, trans fats, hydrogenated oils, filling agents, binders, and nuts, it is a safe choice for those with dietary sensitivities, ensuring you receive high-quality methylated multivitamin supplements.

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