10 Best flea medicine for dogs (2025)

10 Best flea medicine for dogs in 2025 offers a range of effective solutions to keep your furry friend free from pesky parasites. Top contenders include Frontline Plus, which provides long-lasting protection, and NexGard, a tasty chewable that kills fleas quickly. Seresto's innovative collar offers up to eight months of continuous defense, while Advantage II targets both fleas and their eggs. Other notable options include Bravecto, Capstar, and PetArmor, each designed to suit different needs and preferences. With these top-rated products, you can ensure your dog remains comfortable and healthy, free from the discomfort of fleas.

SaleBestseller No. 1

Frontline Plus Flea and Tick Treatment for Large Dogs Up to 45 to 88 lbs. 3 Treatments

Keep your dog protected from fleas & ticks all month long with FRONTLINE Plus for Dogs a fast-acting, waterproof flea & tick topical that's proven to kill fleas, flea eggs, flea larvae, chewing lice, and ticks that can transmit Lyme disease
Break the flea life cycle with FRONTLINE Plus, specially formulated with fipronil and (S)-methoprene to kill existing adult fleas, flea eggs and flea larvae to guard against further infestations for flea control
Trusted by pet owners for over 20 years, FRONTLINE Plus for Dogs can be used on puppies as young as eight weeks old, weighing 5 pounds or more, and is easy to apply with one monthly dose providing protection from fleas & ticks for a full 30 days
FRONTLINE Plus also comes in a formula designed for cats and kittens eight weeks of age and older, 1.5lbs. and over, so you can protect the dogs or cats in your house from fleas and ticks with FRONTLINE Brand Products
Treat all dogs or cats in your household monthly to effectively control fleas and ticks and prevent the establishment of new flea infestations

Bestseller No. 2

Activate II Flea and Tick Prevention for Dogs | 4 Count | Large Dogs 21-55 lbs | Topical Drops | 4 Months Flea Treatment

COMPARE TO K9 ADVANTIX II: Activate II uses Imidacloprid, Permethrin, and Pyriproxyfen - the same safe, fast acting active ingredients used in Advantix II for Dogs. Includes 4 monthly doses
ACTIVELY PROTECTS YOUR DOG: Activate II is approved by veterinarians to repel and kill fleas and ticks on contact - before your dog is exposed to bites and potential flea borne illnesses
STOP INFESTATIONS FAST: Our topical drops prevent infestations by breaking the flea life cycle - our insect growth regulator (IGR) starts killing flea eggs and larvae within 12 hours of application
EASY TO APPLY: Simply apply to the base of your dog's neck, and the waterproof solution will travel across the skin - providing continuous protection for 30 days per application
MADE IN AMERICA - RESULTS GUARANTEED: TevraPet Activate II is made to the quality standard we demand for our own pets. We're proud to help you protect your dog with confidence

Bestseller No. 3

K9 Advantix II Large Dog Vet-Recommended Flea, Tick & Mosquito Treatment & Prevention | Dogs 21-55 lbs. | 1-Mo Supply

K9 Advantix II Large Dog 30-day treatment & prevention protects dogs 21-55 lbs. from fleas, ticks, mosquitoes, biting flies and lice
Kills fleas within 12 hours of application
Vet-recommended formula kills & repels on contact so fleas don’t have to bite your dog to die
Easy-to-apply topical treatment is fragrance-free and waterproof after 24 hours
No prescription needed

Bestseller No. 4

CAPSTAR Oral Flea Treatment for Dogs, Fast Acting Tablets Start Killing Fleas in 30 Minutes, Medium & Large Dogs (Over 25 lbs), 6 Doses

FAST-ACTING FLEA TREATMENT: CAPSTAR (nitenpyram) starts killing adult fleas in just 30 minutes
TACKLE FLEA INFESTATIONS FAST: With one dose of CAPSTAR, you can watch the dead fleas fall off your pet
TREAT REINFESTATIONS FAST: If your pet gets reinfested with fleas, simply give another dose as often as once a day
NO PRESCRIPTION NEEDED: Fast, effective flea treatment for dogs that's available over the counter
INTENDED USE: CAPSTAR Oral Flea Treatment for Large Dogs (57 mg) is safe for dogs and puppies 4 weeks and older that weigh 25.1-125 pounds

SaleBestseller No. 5

PetArmor Plus Flea and Tick Prevention for Dogs, Dog Flea and Tick Treatment, 3 Doses, Waterproof Topical, Fast Acting, Large Dogs (45-88 lbs)

EFFECTIVE, WATERPROOF FLEA TREATMENT FOR DOGS: PetArmor Plus is a waterproof, flea & tick topical prevention for dogs that kills fleas, flea eggs, flea larvae, ticks, and chewing lice for up to 30 days after application.
TRUSTED, VET QUALITY* FORMULA: Containing fipronil and (S)-methoprene, the same active ingredients as FRONTLINE Plus for Dogs. PetArmor Plus for Dogs has a powerful formula that starts to kill fleas within 24 hours.
BREAK THE FLEA CYCLE: Unlike other flea and tick treatments that may temporarily suppress flea activity, PETARMOR Plus Dog Flea Treatment works by effectively breaking the flea life cycle! Kill flea eggs and larvae to prevent re-infestation.
FAST ACTNG LONG-LASTING FLEA AND TICK PROTECTION: One application of PetArmor Plus lasts up to 30 days nose to tail. A 6-dose package lasts up to six months.
EASY-TO-USE, LONG-LASTING: PetArmor Plus flea and tick treatment comes with three (3) waterproof topical applications that provides your pet flea protection and control for three (3) months.

Bestseller No. 6

K9 Advantix II XL Dog Vet-Recommended Flea, Tick & Mosquito Treatment & Prevention | Dogs Over 55 lbs. | 2-Mo Supply

K9 Advantix II Extra Large Dog 30-day treatment & prevention protects dogs over 55 lbs. from fleas, ticks, mosquitoes, biting flies and lice
Kills fleas within 12 hours of application
Vet-recommended formula kills & repels on contact so fleas don’t have to bite your dog to die
Easy-to-apply topical treatment is fragrance-free and waterproof after 24 hours
No prescription needed

Bestseller No. 7

Amazon Brand - Solimo for Dogs Large Dog (45-88 pounds) Flea and Tick Treatment, 6 Doses

Same product, new look – This product is identical in manufacturing and formulation as the Solimo brand
One 6 dose pack of Amazon Basics Flea and Tick Topical Treatment for Large Dogs (45 - 88 pounds), 6 Count (Previously Solimo)
Amazon Basics Flea & Tick starts eliminating fleas and ticks within 24 hours of treatment
Active ingredients Fipronil and (s)-methoprene prevent flea infestations by killing flea eggs, flea larvae, mosquitos, biting flies and chewing lice
One application provides up to 30 days of protection

Bestseller No. 8

Amazon Basics Flea and Tick Topical Treatment for Small Dogs (5-22 pounds), 3 Count (Previously Solimo)

Same product, new look - This product is identical in manufacturing and formulation as the Solimo brand
One 3 dose pack of Amazon Basics Flea and Tick Treatment for Dogs, Small (5-22 lbs), 3 Count (Previously Solimo)
Amazon Basics Flea & Tick starts eliminating fleas and ticks within 24 hours of treatment
Active ingredients Fipronil and (s)-methoprene prevent flea infestations by killing flea eggs, flea larvae, mosquitos, biting flies and chewing lice
One application provides up to 30 days of protection

SaleBestseller No. 9

Frontline Plus Flea and Tick Treatment for Small Dogs Upto 5 to 22 lbs. 3 Treatments

Keep your dog protected from fleas & ticks all month long with FRONTLINE Plus for Dogs a fast-acting, waterproof flea & tick topical that's proven to kill fleas, flea eggs, flea larvae, chewing lice, and ticks that can transmit Lyme disease
Break the flea life cycle with FRONTLINE Plus, specially formulated with fipronil and (S)-methoprene to kill existing adult fleas, flea eggs and flea larvae to guard against further infestations for flea control
Trusted by pet owners for over 20 years, FRONTLINE Plus for Dogs can be used on puppies as young as eight weeks old, weighing 5 pounds or more, and is easy to apply with one monthly dose providing protection from fleas & ticks for a full 30 days
FRONTLINE Plus also comes in a formula designed for cats and kittens eight weeks of age and older, 1.5lbs. and over, so you can protect the dogs or cats in your house from fleas and ticks with FRONTLINE Brand Products
Treat all dogs or cats in your household monthly to effectively control fleas and ticks and prevent the establishment of new flea infestations

Bestseller No. 10

Amazon Brand - Solimo for Dogs Medium Dog (23-44 pounds) Flea and Tick Treatment, 6 Doses

Same product, new look – This product is identical in manufacturing and formulation as the Solimo brand
One 6 dose pack of Amazon Basics Flea and Tick Topical Treatment for Medium Dogs (23 - 44 pounds), 6 Count (Previously Solimo)
Amazon Basics Flea & Tick starts eliminating fleas and ticks within 24 hours of treatment
Active ingredients Fipronil and (s)-methoprene prevent flea infestations by killing flea eggs, flea larvae, mosquitos, biting flies and chewing lice
One application provides up to 30 days of protection

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