10 Best enzyme cleaner for dog urine (2025)

10 best enzyme cleaners for dog urine in 2025 offer effective solutions for pet owners dealing with stubborn stains and odors. These specialized cleaners utilize natural enzymes to break down urine components, ensuring thorough removal without harsh chemicals. Top products on the market include Nature's Miracle, Rocco & Roxie, and Simple Solution, each praised for their powerful formulas and ease of use. Additionally, brands like PetStain and Bubba's Rowdy Friends provide eco-friendly options that are safe for pets and children. With these enzyme cleaners, maintaining a fresh and clean home is easier than ever for dog owners.

SaleBestseller No. 1

Nature's Miracle Dog Stain and Odor Remover, Everyday Mess Enzymatic Formula, 32 fl oz

SPOT STAIN & ODOR REMOVER: Begins to break down and remove stains immediately on contact.
LIGHT CITRUS SCENT: Dog odor control formula gets your home smelling clean again.
ENZYMATIC FORMULA: Continues working as long as any bio-based mess is still present.
TRUSTED BRAND: From the maker of Nature’s Miracle products, the pet stain and odor removing brand you trust… because it works!
SAFE FOR PETS AND HOME: When used and stored as directed, this formula can be used around your pets.

SaleBestseller No. 2

Rocco & Roxie Supply Co. Stain & Odor Eliminator for Strong Odor, 32oz Enzyme Pet Odor Eliminator for Home, Carpet Stain Remover for Cats & Dog Pee, Enzymatic Cat Urine Destroyer, Carpet Cleaner Spray

Certified Gentle And Safe: Chlorine free and color safe; Safe to use around pets and children; No hazardous propellants, no residue left behind. So gentle it’s been Certified Safe for all carpets, earning the Seal of Approval by the trusted Carpet and Rug Institute (cri)
Eliminates Stains, Odors and Residue: If it’s gross, it’s gone; Not just the stain, but the stink; From stinky yellow pet urine and feces to vomit and other organic spills, our professional strength formula tackles them all
Every Surface, Every Time: For use on carpets, floors, furniture, clothing, litter boxes, kennels, carriers, all pet living and sleeping areas—anywhere stains happen
Enzyme Activated: The key is getting to the problem deep-down; This spray contains natural enzymes that are activated on contact with odors and stains, feeding on ammonia crystals and organic matter until they are completely eliminated
Buy With Confidence: You want the best for your best friend; We do, too; If you are not satisfied with the performance of this product, contact us; We are determined to make it right

Bestseller No. 3

AmazonCommercial Multi-Purpose Enzyme Cleaner, Mint, 1 gallon, 128 fl oz (Pack of 1)

1 gallon bottle of multi-purpose enzyme cleaning solution for a wide variety of surfaces and environments – use on carpets, furniture, hardwood, tile, drains, liter boxes, garbage cans, RVs and more
Breaks up complex organic proteins, pet smells and stains, grease, oils, and more for effective results
Powerful enzymatic formula removes stains and odors deep in the carpet
Attack grease, fats and other organic matter that cause slow drains and unpleasant odors - not effective on bathroom clogs due to hair like a hazardous caustic drain opener
Non-corrosive, non-flammable, non-acidic, and non-caustic with a fresh mint scent

SaleBestseller No. 4

Nature's Miracle Urine Destroyer Plu for Dogs, Enzymatic Formula for Severe Dog Urine Stains, 32 fl oz

FOR DOG URINE MESSES: Begins to break down and remove stains immediately on contact.
POWERFUL FORMULA: Just soak the affected area, allow to work for 15 minutes, then blot up stain with a clean cloth.
ENZYMATIC FORMULA: Continues working as long as any bio-based mess is still present.
MADE WITH RECYCLED MATERIAL: Our bottles are made with 25% Post-Consumer Recycled Material.
SAFE FOR PETS AND HOME: When used and stored as directed, this formula can be used around your pets and in your home

SaleBestseller No. 5

Nature's Miracle Advanced Stain and Odor Eliminator Dog for Severe Dog Messes

FOR SEVERE DOG MESSES: Powerful enzymatic formula works to eliminate tough stains and odors from dog urine, diarrhea, vomit and other bio-based accidents.
LIGHT FRESH SCENT: Dog odor control formula gets your home smelling clean again.
ENZYMATIC FORMULA: Continues working as long as any bio-based mess is still present.
DISCOURAGES RESOILING: Removes the odor from even the toughest dog messes.
TRUSTED BRAND: From the maker of Nature’s Miracle products, the pet stain and odor removing brand you trust because it works

Bestseller No. 6

Simple Solution Extreme Pet Stain and Odor Eliminator Spray, Enzymatic Cleaner With 3X Pro-Bacteria Cleaning Power for Dogs & Cats, Strong Urine, Pee and Poop Smell Remover for Carpets & Floors, 32 oz

PET STAIN AND ODOR REMOVER: Things can get a little messy when your pet is involved - that’s where we come in; This extra-strength cleaning solution is specially formulated to tackle the toughest smells & dirtiest spots left behind by your beloved pets.
EXTREME ENZYMATIC CLEANER: This professional strength spray consists of a powerful enzyme formula three times stronger than our regular formula, specialized for breaking down, eliminating, and permanently neutralizing both new and old stains and odors.
FOR DOGS AND CATS: Say goodbye to bad messes - This dog and cat-specific cleaning spray is the best thing for cleaning up after urine, feces, vomit, and all the stains and smells that accompany them; It is a pet-safe and family-friendly cleaning option
MULTIFUNCTION SPRAY: This cleaner can be used for carpets, upholstery, bedding, fabric toys, clothing, & other water-safe surfaces in your home; It uses a patented 3-in-1 nozzle with mist, foam, and stream features so you can pick the best way to clean up
SIMPLE SOLUTION: it’s just that…a simple solution to all of your pets’ messes – wherever they may be; We offer easy-to-use, no-hassle products that will effectively help you keep your home clean and sparkling; In short - pet parenting made easy.

Bestseller No. 7

Pet Odor and Stain Eliminator - 32 oz ACTIVE Enzyme Cleaner for Dog & Cat Urine, Stain Remover Spray for Carpet, Upholstery, Hardwood, Spot Cleaning, Deodorizer for Dogs Cats Pets - Natural Citrus Oil

Completely Eliminate Odors & Stains: Our ready-to-use Advanced Pet Odor Eliminator Sprays target the source of animal messes, Lifting Stains and Removing Smells, leaving behind only a Pleasant Citrus Oil Scent! Compare to other products that only mask the problem instead of actually deodorizing
Bio Enzymatic Odor Destroyer: ACTIVE Pet Stain and Odor Remover Formula is specially made with Enzymes and Natural Probiotics that Remove Smell from Puppy Accidents, Cat Urine, and all odour from Pee, Poop, Vomit, Litter and more
Professional Stain Removal: ACTIVE Enzyme Cleaners will easily get rid of mess and set-in stains in Carpets, Fabric, Floor. Our powerful Stain Eliminating Solution creates a Deep Cleaning Lather with every Spray for full Stain Treatment
Designed for Home Surfaces: Universal Indoor Pet Clean-up Spray for couch stains, Wood Floors, Rug, Furniture, Mattress, Dog bed, Kennel- wherever your pet goes! Get any hard to clean accident in the house with ACTIVE deodorizers and animal stain removers
Proudly Made in USA: ACTIVE Pet Odor Neutralizer Spray is made entirely in the United States with just the best components and ingredients. Our Formula is gentle yet Effective, and Safe to use around Pets and Kids

Bestseller No. 8

Bioda Multi-Purpose Probiotic Enzyme Cleaner and Deodorizer | Professional Strength | Trash Can Deodorizer, Pet Stains and Odors, Drains, Floors, Bathrooms, Toilets | Made in USA | 1 Gallon

THE POWER OF ONE: This versatile product is the only probiotic cleaner you need, providing powerful cleaning performance in a wide variety of applications. Multipurpose use: Maintain clean drain lines and septic tanks to prevent clogs and potential buildup. Clean and deodorize trash bins, stains and odors on floors, carpets, bathroom surfaces, kitchen surfaces, and more.
ACTIVE UP TO 21 DAYS: Our specialized probiotics continue to clean soils in cracks, grout and tough to reach places. Simply spray & let the probiotics do the dirty work!
NATURALLY, SUPERIOR RESULTS: A special blend of enzyme-producing probiotics break down complex proteins, fats, oils, greases, and other organic waste. The enzymes digest the soils until they have been eliminated, providing a long-lasting, continuous clean without leaving a residue or harmful by-products behind.
ELIMINATE ODOR: Provide total odor control by eliminating the actual source of even the most pungent organic malodors naturally, including rotting food, urine, feces, vomit, and trash. Plus, the fresh lemon and sage fragrance leaves behind a light, pleasant scent that rejuvenates the air of any environment.
MADE IN THE USA - 1 Gallon Bottle

Bestseller No. 9

Resolve Urine Destroyer Spray – Pet Stain and Odor Remover, Carpet Cleaner Solution for Cat and Dog Urine, 32 Fl Oz

DESTOYS URINE ODORS THE FIRST TIME: Urine elimination technology neutralizes and removes odors on contact for immediate freshness
REMOVES PET STAINS AND MORE: Effectively tackles pet stains, food stains, and other tough messes
HELPS PREVENT REMARKING: Discourages pets from returning to make a mess in the same spot
SUITABLE FOR USE AROUND PETS: Suitable for use around pets when used as directed
MULTIPURPOSE USE: Effective on most carpets, fabrics and hard surfaces for versatile cleaning

Bestseller No. 10

Nature's Miracle Stain and Odor Remover Dog, Odor Control Formula, Accushot Spray 1.33 Gal

SPOT STAIN & ODOR REMOVER: Begins to break down and remove stains immediately on contact
LIGHT CITRUS SCENT: Dog odor control formula gets your home smelling clean again
ACCUSHOT SPRAYER REFILL: Use alone or with the AccuShot continuous power sprayer (sold separately)
ENZYMATIC FORMULA: Continues working as long as any bio-based mess is still present
SAFE FOR PETS AND HOME: When used and stored as directed, this formula can be used around your pets

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