10 Best digestive enzymes supplement (2025)

10 Best digestive enzymes supplements in 2025 offer a range of benefits for those seeking to enhance their digestive health. These supplements are formulated with a blend of enzymes like amylase, protease, and lipase, which aid in breaking down carbohydrates, proteins, and fats. Leading brands such as Garden of Life, NOW Foods, and Enzymedica have gained popularity for their high-quality ingredients and effectiveness. Users report improved digestion, reduced bloating, and increased nutrient absorption. As digestive health continues to be a priority, these top supplements provide a convenient solution for maintaining optimal gut function.

SaleBestseller No. 1

Physician's CHOICE Digestive Enzymes - Multi Enzymes, Organic Prebiotics & Probiotics for Digestive Health & Gut Health - Meal Time Discomfort Relief & Bloating - Dual Action Approach - 60 CT

Beat the Bloat & Say Goodbye to Meal Time Discomfort: 16 beneficial enzymes that digest proteins, carbs, fruits, veggies, beans, dairy, & fats to cover all diets. With SBO Probiotics & Prebiotics to aid digestion further - Your New Meal Time Hack!
Dual Action Relief: Our powerful digestive enzymes aid with breaking down food while the prebiotics & probiotics promote digestive function in the gut. They work synergistically to provide relief from mealtime discomfort.
Probiotics that Survive the Gut: Formulated with 3 soil-based probiotic strains - specifically selected due to their ability to survive the harsh gut environment. Along with Organic Prebiotics that fuel the growth of healthy bacteria in the gut.
Science Backed - Our Digestive Enzyme Probiotics are crafted based on scientific research. We have partnered with expert physicians to help review our products & research. We strive to educate & help you with informed decisions regarding your health.
Safety Assured Standard of Quality: Our Digestive Enzymes are 3rd-party tested for purity and potency. Each bottle is manufactured w/ love & care in the USA with strict quality control - using imported & domestic ingredients. No Refrigeration Needed

Bestseller No. 2

Digestive Enzymes - 800mg Blend of All 10 Most Essential Digestive and Pancreatic Enzymes (Amylase, Lipase, Bromelain, Lactase, Papain, Protease, Cellulase, Maltase, Invertase) by Double Wood

CONTAINS ALL 10 MOST ESSENTIAL DIGESTIVE ENZYMES: No other digestive enzyme blend contains all 10 most essential digestive enzymes including Amylase, Lipase, Bromelain, Lactase, Papain, Protease, Cellulase, Maltase, Invertase, and Glucoamylase
TOP 3 PANCREATIC ENZYMES INCLUDED: The Amylase pancreatic enzyme breaks down starches and carbohydrates into sugars. The Lipase enzyme breaks down fats and oils, into glycerol and fatty acids. Lastly, the Protease enzymes break down proteins into amino acids
VITAZYME DIGESTIVE AID: Double Wood's trademarked digestive enzyme supplement aids digestion and supports overall digestive health. Delivering super enzymes to help with bloating relief
BREAKDOWN PROTEIN, FATS, AND CARBOHYDRATES: Double Wood's Vitazyme blend contains the most essential digestive and pancreatic enzymes needed to break down fats, proteins, and carbohydrates
WE BOTTLE WELLNESS: At Double Wood we provide pure, potent supplements that deliver exceptional value, all backed by careful sourcing and rigorous third-party testing

Bestseller No. 3

NOW Foods Supplements, Super Enzymes, Formulated with Bromelain, Ox Bile, Pancreatin and Papain,180 Capsules

SUPPORTS HEALTHY DIGESTION*: NOW Super Enzymes is a comprehensive blend of enzymes that supports healthy digestion.* Take one capsule with a meal.
BREAKS DOWN FATS, CARBS, AND PROTEINS*/OPTIMIZES NUTRIENT AVAILABILITY*: Formulated with bromelain, ox bile, pancreatin and papain, Super Enzymes helps to optimize the breakdown of fats, carbohydrates and protein.*
CERTIFICATIONS/CLASSIFICATIONS: Soy Free, Made without Gluten, Keto Friendly
GMP Quality Assured: NPA A-rated GMP certification means that every aspect of the NOW manufacturing process has been examined, including our laboratory/testing methods (for stability, potency, and product formulation).
Packaged in the USA by a family owned and operated company since 1968.

Bestseller No. 4

Zenwise Health Digestive Enzymes for Gut Health - Probiotic Multi Enzymes with Prebiotics and Probiotics for Women and Men for Digestive Health and Bloating Relief, Daily Enzymes for Digestion -100 CT

3-in-1 Formula – Blend of lab proven enzymes, clinically proven probiotics and prebiotics works synergistically to break down proteins, fats, and carbs while resorting digestive flora balance for optimal nutrient absorption and digestion maintain digestive wellness and promote regularity
Fast-Acting Enzymes – Powerful enzyme blend starts working immediately to break down food up to 39% more completely, and ease indigestion for rapid, noticeable relief
Proven Probiotics – Guaranteed to arrive alive and work within hours in the small intestine where 90% of nutrient absorption occurs
Gas & Bloating Relief - Targeted enzymes work with beneficial microflora to ease uncomfortable bloating, reduce gas, and soothe digestive discomfort naturally
Plant-Based Formula - Pure vegetarian enzymes combined with prebiotic fiber nourish your microbiome while supporting healthy digestion and immune function – take 1 capsule before your meal to experience digestive delight

Bestseller No. 5

Pure Encapsulations Digestive Enzymes Ultra - Vegetarian Digestive Enzyme Supplement to Support Protein, Carb, Fiber, and Dairy Digestion* - 90 Capsules

Nutrient Absorption: Contains a mixture of vegetarian enzymes developed to support nutrient bioavailability and absorption; supports digestion*
Supports Digestion: Facilitates the normal breakdown of proteins, peptides, polysaccharides and disaccharides; assists with dairy, fiber, and protein digestion*
Digestive Enzymes: Offers a broad-spectrum combination of vegetarian digestive enzymes designed to provide optimal activity across a wide pH range
Dairy Enzyme Blend: This vegetarian enzyme blend supports digestion of dairy, sugar, lactose, and certain complex carbs; supports relief from occasional gas or bloating
Pure Difference: What we leave out matters, too; Pure Encapsulations products are free from common allergens, artificial or unnecessary ingredients, and GMOs

Bestseller No. 6

Wholesome Wellness Digestive Enzymes 1000MG Plus Prebiotics & Probiotics Supplement, 180 Capsules, Organic Plant-Based Vegan Formula for Digestion & Lactose with Amylase & Bromelain,3-6 Months Supply

Get Digestive Comfort Now – Ultra Strength 1000 MG Dose of clinical grade digestive enzymes and a 10 billion CFU 10 strain probiotic with prebiotics. Get results & relief fast with more than double the dose of other digestive enzyme supplements. Using organic, systemic, Dr. formulated, & plant based ingredients to ensure the best healthy digestion for adult men & women. Anti bloating, flatulence, fat, pancreatic, & bowel cleansing with Turmeric, Ginger, Papaya, Pectin, Bladderwrack & more.
Goodbye Hard-to-Digest Foods – This formula features our Advanced Multi Enzyme System to help you digest fried, spicy, raw, processed food, dairy, protein, salts, carb / carbohydrate, vitamin and acidic diet fruits and veggies. Immune-Boosting Probiotic – The gut, biofilm & gallbladder is home to 50% of the body’s immune repair response and this supplement contains a powerful 10 billion CFU dose of 10 different probiotic strains clinically shown to enhance preventions & immune system response.
Relieve Gas, Belly Bloating / Bloat, Constipation, Leaky, Indigestion, Reflux, Belching & Acid Discomfort! Aid gut health, beauty & bloated stomach comfort. Prebiotic fiber, probiotic encapsulation(Lactobacillus acidophilus, plantarum, casei, salivarius, bulgaricus and Bifidobacterium lactis, bifidum, breve, longum), & enzymes support gut flora bacteria, bile, nutrient absorption, motility, & enzyme levels your body isn't producing as you age.
Complete digestive enzyme pills complex blend with essential organic blue agave heart, inulin, amylase / amilasa, papain, protease A, invertase, cellulase, hemicellulase, lactase, lipase / lipasa, alpha-galactosidase, fungal pepsin, glucomylase, & bromelina & bromelain supplement. Plus your probiotic supplement and prebiotic supplement (pre & pro) at the same time. All in a convenient purified cap / capsule form which you can open and take as a chewable with dietary nutrients, super food or meal
Proudly made in the USA in a GMP certified manufacturing facility, 3rd Party Tested, and a 100% satisfaction money back guarantee. If you are not satisfied with our products for any reason, let us know and we’ll make it right. This product is vegan, non-GMO, pure, natural, gluten free, cGMP, wise, dairy free, zen, organic ingredients and is free of soy, peanuts, eggs, gelatin, ox, shellfish, artificial sweeteners, colors, & flavors.

Bestseller No. 7

THORNE Advanced Digestive Enzymes (Formerly Bio-Gest) - Blend of Digestive Enzymes to Aid Digestion - Gut Health Support with Pepsin, Ox Bile, Pancreatin - 180 Capsules - 90 Servings

Support for Indigestion: Benefits individuals who have occasional indigestion, food sensitivities, gallbladder removal, or who have overused antacids*
Comprehensive Formula: A blend of hydrochloric acid, pepsin, pancreatin, and ox bile
Promotes Digestion: Can help ease digestive discomfort that may occur after a meal heavy in fat or red meat, when enjoying foods that cause extra gas and bloating, or when partaking in an occasional overindulgence
Promotes Nutrient Absorption: Benefits absorption of vitamins, minerals, and other nutrients*
Trusted: Thorne is trusted by 45,000 health-care professionals and 100+ pro teams and U.S. Olympic teams. Thorne is the only supplement manufacturer to collaborate with Mayo Clinic on wellness research and content

SaleBestseller No. 8

Enzymedica Digest Gold + ATPro, Maximum Strength Digestive Enzymes, Helps Digest Large Meals for Instant Bloating Relief, 45 Count

For Food Lovers: Savor your favorite dishes worry-free; Our full-strength, bloat-busting digestive enzyme blend helps break down large meals faster, easing bloating and occasional indigestion for care-free indulgence*
ATPro Blend: Beat the post-meal blues and feel fueled with energy to power through your day; This unique formula features ATPro, a proprietary blend of ATP, Magnesium Citrate, Phytase and CoQ10 that helps fuel your body's cells*
Effective All the Way Through: Our proprietary Thera-blend enzymes are formulated for optimal activity throughout the digestive system's varying pH levels, providing faster relief and maximum digestive support*
Dosage: Just 1 capsule daily breaks down up to 34g fat, 16g protein and 86g carbs; Contains no gluten, milk, casein, soy, egg, artificial colors, flavors, or GMOs; Vegan, Kosher and Clean Label Project Certified
Making a Difference: Enzymedica products harness the power of the finest natural ingredients for maximum effectiveness; We create quality products without compromise while championing initiatives that support the well-being of people and our planet

SaleBestseller No. 9

Sports Research Digestive Enzymes with Probiotics & Ginger - Plant Based for Dairy, Protein, Sugar & Carbs - Non-GMO Verified & Vegan Friendly (90 Veggie Capsules)

COMPLETE GUT WELLNESS: With 15 enzymes plus probiotics and ginger— these veggie capsules are here to promote better nutrient absorption, encourage proper digestion, and help promote stomach regularity*
HELP EASE STOMACH DIGESTION: Digestive Enzymes from Sports Research is specially formulated to help you digest proteins, fats, fruits, vegetable fiber, dairy products, and carbohydrates, resulting in better nutrient absorption and less digestive discomfort*
BEAT THE BLOAT: Replenishes enzymes that may decline with age. Our plant-based digestive enzymes with probiotics and ginger work synergistically to help tackle hard-to-digest foods and stomach bloating*
QUALITY ASSURED: We hold all of our supplements to a higher standard. Rest assured that your digestive enzymes capsules are manufactured in a cGMP-compliant USA facility and third-party tested for quality. Our digestive enzymes capsules are Non-GMO Project Verified, Vegan Friendly, and free of gluten, soy, and unwanted fillers
THE SPORTS RESEARCH DIFFERENCE: Founded in Southern California in 1980, Sports Research is a family-owned business born from a passion for fitness and wellness. Our goal is to embrace the sport of life through research-backed products created for every body—inside and out (Please remove product label before recycling bottle)

Bestseller No. 10

NatureBell Digestive Enzymes with Probiotics and Prebiotics, 240 Veggie Capsules | Gut & Digestive Health Support – 20 Enzyme & 5 Prebiotic Pancreatic Enzyme Complex | Non-GMO, Vegan Friendly

Digestive Enzyme and Prebiotic complex with 240 veggie capsules, one capsule serving for an 8-month supply, take one per meal daily for up to three meals for the first week, then only once daily after that for optimal benefits.
Each serving delivers 400mg total, combining 20 enzymes with 5 prebiotics including 200mg of psyllium husk, inulin, acacia senegal, FOS, and chia seed, as well as 200mg of carbs, proteins, fibers, fats, and lactose enzymes.
Designed for both women and men, this full spectrum blend supports digestion, nutrient absorption, bloating, and overall gut health.
A synergistic mix that may promote a balanced gut flora, providing daily digestive balance with its unique combination of enzymes and prebiotics.
Authentic non-GMO digestive enzyme supplement. Contains pure ingredients free of soy, dairy, gluten, wheat, preservatives, eggs, fish, and tree nuts. All products are also 3rd party lab tested for safety and potency.

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