10 Best digestive enzymes (2025)

10 Best Digestive Enzymes (2025) are essential for promoting optimal gut health and enhancing nutrient absorption. These powerful supplements include protease, amylase, and lipase, which help break down proteins, carbohydrates, and fats, respectively. Popular options like Garden of Life's Raw Enzymes and Enzymedica's Digest Gold stand out for their high potency and diverse enzyme profiles. Other notable mentions include NOW Foods' Super Enzymes and Source Naturals' Essential Enzymes, both known for their effectiveness. Incorporating these digestive enzymes into your daily routine can alleviate bloating, improve digestion, and support overall wellness, making them a must-have for health-conscious individuals.

SaleBestseller No. 1

Physician's CHOICE Digestive Enzymes - Multi Enzymes, Organic Prebiotics & Probiotics for Digestive Health & Gut Health - for Meal Time Discomfort Relief & Bloating - Dual Action Approach - 90 CT

Beat the Bloat & Say Goodbye to Meal Time Discomfort: 16 beneficial enzymes that digest proteins, carbs, fruits, veggies, beans, dairy, & fats to cover all diets. With SBO Probiotics & Prebiotics to aid digestion further - Your New Meal Time Hack!
Dual Action Relief: Our powerful digestive enzymes aid with breaking down food while the prebiotics & probiotics promote digestive function in the gut. They work synergistically to provide relief from mealtime discomfort.
Probiotics that Survive the Gut: Formulated with 3 soil-based probiotic strains - specifically selected due to their ability to survive the harsh gut environment. Along with Organic Prebiotics that fuel the growth of healthy bacteria in the gut.
Science Backed - Our Digestive Enzyme Probiotics are crafted based on scientific research. We have partnered with expert physicians to help review our products & research. We strive to educate & help you with informed decisions regarding your health.
Safety Assured Standard of Quality: Our Digestive Enzymes are 3rd-party tested for purity and potency. Each bottle is manufactured with love & care in the USA with strict quality control - using imported and domestic ingredients.

SaleBestseller No. 2

NOW Foods Supplements, Super Enzymes, Formulated with Bromelain, Ox Bile, Pancreatin and Papain, Super Enzymes,90 Capsules

SUPPORTS HEALTHY DIGESTION: NOW Super Enzymes is a comprehensive blend of enzymes that supports healthy digestion. Take one capsule with a meal.
Product Note: Exposure to heat or sunlight may lead to melting/damage of product. Hence customers are expected to be available during the product delivery
BREAKS DOWN FATS, CARBS, AND PROTEINS/OPTIMIZES NUTRIENT AVAILABILITY: Formulated with bromelain, ox bile, pancreatin and papain, Super Enzymes helps to optimize the breakdown of fats, carbohydrates and protein.
CERTIFICATIONS/CLASSIFICATIONS: Soy Free, Made without Gluten, Keto Friendly
GMP Quality Assured: NPA A-rated GMP certification means that every aspect of the NOW manufacturing process has been examined, including our laboratory/testing methods (for stability, potency, and product formulation).

Bestseller No. 3

Zenwise Health Digestive Enzymes for Gut Health - Probiotic Multi Enzymes with Prebiotics and Probiotics for Women and Men for Digestive Health and Bloating Relief, Daily Enzymes for Digestion -45 CT

3-in-1 Formula – Blend of lab proven enzymes, clinically proven probiotics and prebiotics works synergistically to break down proteins, fats, and carbs while resorting digestive flora balance for optimal nutrient absorption and digestion maintain digestive wellness and promote regularity
Fast-Acting Enzymes – Powerful enzyme blend starts working immediately to break down food up to 39% more completely, and ease indigestion for rapid, noticeable relief
Proven Probiotics – Guaranteed to arrive alive and work within hours in the small intestine where 90% of nutrient absorption occurs
Gas & Bloating Relief - Targeted enzymes work with beneficial microflora to ease uncomfortable bloating, reduce gas, and soothe digestive discomfort naturally
Plant-Based Formula - Pure vegetarian enzymes combined with prebiotic fiber nourish your microbiome while supporting healthy digestion and immune function – take 1 capsule before your meal to experience digestive delight

Bestseller No. 4

Pure Encapsulations Digestive Enzymes Ultra - Vegetarian Digestive Enzyme Supplement to Support Protein, Carb, Fiber, and Dairy Digestion* - 90 Capsules

Nutrient Absorption: Contains a mixture of vegetarian enzymes developed to support nutrient bioavailability and absorption; supports digestion*
Supports Digestion: Facilitates the normal breakdown of proteins, peptides, polysaccharides and disaccharides; assists with dairy, fiber, and protein digestion*
Digestive Enzymes: Offers a broad-spectrum combination of vegetarian digestive enzymes designed to provide optimal activity across a wide pH range
Dairy Enzyme Blend: This vegetarian enzyme blend supports digestion of dairy, sugar, lactose, and certain complex carbs; supports relief from occasional gas or bloating
Pure Difference: What we leave out matters, too; Pure Encapsulations products are free from common allergens, artificial or unnecessary ingredients, and GMOs

Bestseller No. 5

Source Naturals Essential Enzymes 500mg Bio-Aligned Multiple Enzyme Supplement Herbal Defense for Digestion, Gas, Constipation & Bloating Relief - Supports A Strong Immune System - 60 Capsules

Digestive Aid that aids the body’s natural digestive process, helping to maximize the body’s utilization of the nutrients in the diet while supporting digestive comfort.
Formulated to support optimal nutrient utilization, digestive health, and digestive comfort.
Delivers 8 enzymes that break down every food type: proteins, fats, milk sugar, fiber, and carbohydrates.
Works in a wide range of pH levels.
Convenient capsules can be opened and sprinkled over food if desired. DO NOT sprinkle on hot food.*

Bestseller No. 6

Physician's CHOICE Digestive Enzymes - Multi Enzymes, Bromelain, Organic Prebiotics & Probiotics for Digestive Health & Gut Health - Bloating & Meal Time Discomfort - Dual Action - All Diets - 30 CT

Say Goodbye to Meal Time Discomfort: Contains 16 beneficial enzymes that digest proteins, carbs, fruits, veggies, beans, dairy, & fats to cover diverse diets. Includes SBO Probiotics & Prebiotics to aid digestion further - Your New Meal Time Hack!
Dual Action Relief: Our powerful digestive enzymes aid with breaking down food while the prebiotics & probiotics promote digestive function in the gut. They work synergistically to provide relief from mealtime discomfort.
Probiotics that Survive the Gut: Formulated with 3 soil-based probiotic strains - specifically selected due to their ability to survive the harsh gut environment. Along with Organic Prebiotics that fuel the growth of healthy bacteria in the gut.
Science Backed - Our Digestive Enzyme Probiotics are crafted based on scientific research. We have partnered with expert physicians to help review our products & research. We strive to educate & help you with informed decisions regarding your health.
Safety Assured Standard of Quality: Our Digestive Enzymes are 3rd-party tested for purity and potency. Each bottle is manufactured with love & care in the USA with strict quality control - using imported and domestic ingredients.

SaleBestseller No. 7

Ultra Digestive Food Enzymes: Enhance Digestion With This Ultra Digestive Food Enzyme Blend. This supplement is formulated to enable digestion, especially in those with digestive issues, amplifying nutrient absorption.
Multiple Benefits: This extra strength blend of enzymes are formulated to help digest proteins, carbohydrates, fiber, fat, and lactose. This supplement was specifically formulated to support digestion, as well as reduce occasional bloating and gas.
Vegan Formula: We include more of every enzyme that can help you feel your best: Protease, Amylase, Glucoamylase, Diastase, Invertase, Pectinase, Cellulase, Hemicellulase, Xylanase, Lipase, Lactase, Alpha-Galactosidase, and Beta-Glucanase. Our enzymes also include Vitamin B1, B6, B12, Calcium, Magnesium, Manganese, Amla, and Phytase. Other Ingredients: Hypromellose, Maltodextrin, Calcium Phosphate.
Easy Efficient Absorption: Formulated for men and women. Each bottle contains 60 capsules, with a serving size of 1 capsule, and will last 1-2 months. Adults take 1 capsule prior to each meal or as recommended by physician or healthcare professional. Keep out of reach of children in case of accidental overdose or choking. Store in a cool, dry place.
MaryRuth's Ultra Digestive Food Enzymes are Vegan, Non-GMO Project Verified, and Made in a GMP (Good Manufacturing Practice) Facility. Dairy Free, Nut Free, Gluten Free, Soy Free, Sugar Free. Clean Label Project Certified. B Corp Certified.

SaleBestseller No. 8

Garden of Life Dr Formulated Digestive Enzymes with Papain, Bromelain, Lipase for Digestion & Nutrient Absorption – Organic Digest+ - Vegan, Gluten-Free, Non-GMO, Tropical Fruit Flavor, 90 Chewables

BREAK IT DOWN: Organic Digest+ offers 29 Certified Organic fruits and vegetables plus a select blend of 13 powerful digestive enzymes including amylase, bromelain, and lactase to help with digestion after meals
MADE FROM WHOLE FOODS: Dr. Perlmutter formulated Digest+ to be a full spectrum plant-based enzyme formula to aid the digestion of proteins, fats, and carbs; We’ve also included prebiotic fiber from Organic Acacia to support the good bacteria in your gut
BACKED BY SCIENCE: Our Dr. Formulated Organic Digest+ is the first-ever Certified Organic and Non-GMO digestive enzyme formula that is made from real food and is delivered using Clean Tablet Technology to ensure optimal nutrient absorption
CONVENIENCE IN MIND: Transport to the tropics after every last bite; Enjoy the benefits of Organic Digest+ in a tropical flavored, shelf stable tablet thats size makes it easy to take on the go; Adults chew 1 tablet after each meal or snack
EXPERTLY FORMULATED: Our digestive supplement is proudly Dr. Formulated by David Perlmutter, MD and Third-Party Certified Non-GMO, Gluten-Free and Vegan; Made in the USA with no dairy, soy, gluten, peanuts or tree nuts

Bestseller No. 9

Digestive Enzymes - 800mg Blend of All 10 Most Essential Digestive and Pancreatic Enzymes (Amylase, Lipase, Bromelain, Lactase, Papain, Protease, Cellulase, Maltase, Invertase) by Double Wood

CONTAINS ALL 10 MOST ESSENTIAL DIGESTIVE ENZYMES: No other digestive enzyme blend contains all 10 most essential digestive enzymes including Amylase, Lipase, Bromelain, Lactase, Papain, Protease, Cellulase, Maltase, Invertase, and Glucoamylase
TOP 3 PANCREATIC ENZYMES INCLUDED: The Amylase pancreatic enzyme breaks down starches and carbohydrates into sugars. The Lipase enzyme breaks down fats and oils, into glycerol and fatty acids. Lastly, the Protease enzymes break down proteins into amino acids
VITAZYME DIGESTIVE AID: Double Wood's trademarked digestive enzyme supplement aids digestion and supports overall digestive health. Delivering super enzymes to help with bloating relief
BREAKDOWN PROTEIN, FATS, AND CARBOHYDRATES: Double Wood's Vitazyme blend contains the most essential digestive and pancreatic enzymes needed to break down fats, proteins, and carbohydrates
WE BOTTLE WELLNESS: At Double Wood we provide pure, potent supplements that deliver exceptional value, all backed by careful sourcing and rigorous third-party testing

SaleBestseller No. 10

Physician's CHOICE Advanced Gut Health Bundle: 60 Billion Probiotics 30ct + Digestive Enzymes 60ct for Digestive, Gut, and Immune Health Supports Occasional Constipation, Diarrhea, Gas, and Bloating

Optimal Gut Health: Our bundle combines the power of our 60 billion CFU probiotic with Digestive Enzymes to promote a balanced and healthy gut environment. Say goodbye to digestive discomfort.
Enhanced Nutrient Absorption: Our digestive enzymes assist in breaking down food more effectively, helping your body absorb essential nutrients from your diet.
Survives the Gut: From start to finish - this probiotic is designed to survive the gut & maximize the colonization of our strains.
Digestive Comfort: Bid farewell to bloating, gas, and indigestion. The combination of probiotics and digestive enzymes in this bundle supports smoother digestion, reducing discomfort after meals and supporting a flatter stomach.
Convenience and Savings: By bundling our best-selling probiotics and digestive enzymes together, we offer you the convenience of a comprehensive gut health solution in one package. Plus, you’ll save money compared to purchasing these products separately, making it a cost-effective choice for your health and wellness regimen.

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