10 Best digestive enzyme supplements (2025)

10 best digestive enzyme supplements in 2025 offer a range of benefits for those seeking improved gut health and digestion. These supplements are formulated with a blend of enzymes like amylase, protease, and lipase, which help break down carbohydrates, proteins, and fats more efficiently. Top contenders include brands like Garden of Life, Enzymedica, and NOW Foods, known for their high-quality ingredients and effectiveness. Many of these products also include probiotics to enhance gut flora, making them a comprehensive choice for digestive support. With the right supplement, individuals can experience reduced bloating, improved nutrient absorption, and overall digestive wellness.

SaleBestseller No. 1

Physician's CHOICE Digestive Enzymes - Multi Enzymes, Organic Prebiotics & Probiotics for Digestive Health & Gut Health - Meal Time Discomfort Relief & Bloating - Dual Action Approach - 60 CT

Beat the Bloat & Say Goodbye to Meal Time Discomfort: 16 beneficial enzymes that digest proteins, carbs, fruits, veggies, beans, dairy, & fats to cover all diets. With SBO Probiotics & Prebiotics to aid digestion further - Your New Meal Time Hack!
Dual Action Relief: Our powerful digestive enzymes aid with breaking down food while the prebiotics & probiotics promote digestive function in the gut. They work synergistically to provide relief from mealtime discomfort.
Probiotics that Survive the Gut: Formulated with 3 soil-based probiotic strains - specifically selected due to their ability to survive the harsh gut environment. Along with Organic Prebiotics that fuel the growth of healthy bacteria in the gut.
Science Backed - Our Digestive Enzyme Probiotics are crafted based on scientific research. We have partnered with expert physicians to help review our products & research. We strive to educate & help you with informed decisions regarding your health.
Safety Assured Standard of Quality: Our Digestive Enzymes are 3rd-party tested for purity and potency. Each bottle is manufactured w/ love & care in the USA with strict quality control - using imported & domestic ingredients. No Refrigeration Needed

Bestseller No. 2

NOW Foods Supplements, Super Enzymes, Formulated with Bromelain, Ox Bile, Pancreatin and Papain,180 Capsules

SUPPORTS HEALTHY DIGESTION*: NOW Super Enzymes is a comprehensive blend of enzymes that supports healthy digestion.* Take one capsule with a meal.
BREAKS DOWN FATS, CARBS, AND PROTEINS*/OPTIMIZES NUTRIENT AVAILABILITY*: Formulated with bromelain, ox bile, pancreatin and papain, Super Enzymes helps to optimize the breakdown of fats, carbohydrates and protein.*
CERTIFICATIONS/CLASSIFICATIONS: Soy Free, Made without Gluten, Keto Friendly
GMP Quality Assured: NPA A-rated GMP certification means that every aspect of the NOW manufacturing process has been examined, including our laboratory/testing methods (for stability, potency, and product formulation).
Packaged in the USA by a family owned and operated company since 1968.

Bestseller No. 3

Zenwise Health Digestive Enzymes for Gut Health - Probiotic Multi Enzymes with Prebiotics and Probiotics for Women and Men for Digestive Health and Bloating Relief, Daily Enzymes for Digestion -100 CT

3-in-1 Formula – Blend of lab proven enzymes, clinically proven probiotics and prebiotics works synergistically to break down proteins, fats, and carbs while resorting digestive flora balance for optimal nutrient absorption and digestion maintain digestive wellness and promote regularity
Fast-Acting Enzymes – Powerful enzyme blend starts working immediately to break down food up to 39% more completely, and ease indigestion for rapid, noticeable relief
Proven Probiotics – Guaranteed to arrive alive and work within hours in the small intestine where 90% of nutrient absorption occurs
Gas & Bloating Relief - Targeted enzymes work with beneficial microflora to ease uncomfortable bloating, reduce gas, and soothe digestive discomfort naturally
Plant-Based Formula - Pure vegetarian enzymes combined with prebiotic fiber nourish your microbiome while supporting healthy digestion and immune function – take 1 capsule before your meal to experience digestive delight

Bestseller No. 4

Digestive Enzymes - 800mg Blend of All 10 Most Essential Digestive and Pancreatic Enzymes (Amylase, Lipase, Bromelain, Lactase, Papain, Protease, Cellulase, Maltase, Invertase) by Double Wood

CONTAINS ALL 10 MOST ESSENTIAL DIGESTIVE ENZYMES: No other digestive enzyme blend contains all 10 most essential digestive enzymes including Amylase, Lipase, Bromelain, Lactase, Papain, Protease, Cellulase, Maltase, Invertase, and Glucoamylase
TOP 3 PANCREATIC ENZYMES INCLUDED: The Amylase pancreatic enzyme breaks down starches and carbohydrates into sugars. The Lipase enzyme breaks down fats and oils, into glycerol and fatty acids. Lastly, the Protease enzymes break down proteins into amino acids
VITAZYME DIGESTIVE AID: Double Wood's trademarked digestive enzyme supplement aids digestion and supports overall digestive health. Delivering super enzymes to help with bloating relief
BREAKDOWN PROTEIN, FATS, AND CARBOHYDRATES: Double Wood's Vitazyme blend contains the most essential digestive and pancreatic enzymes needed to break down fats, proteins, and carbohydrates
WE BOTTLE WELLNESS: At Double Wood we provide pure, potent supplements that deliver exceptional value, all backed by careful sourcing and rigorous third-party testing

Bestseller No. 5

Wholesome Wellness Digestive Enzymes 1000MG Plus Prebiotics & Probiotics Supplement, 180 Capsules, Organic Plant-Based Vegan Formula for Digestion & Lactose with Amylase & Bromelain,3-6 Months Supply

Get Digestive Comfort Now – Ultra Strength 1000 MG Dose of clinical grade digestive enzymes and a 10 billion CFU 10 strain probiotic with prebiotics. Get results & relief fast with more than double the dose of other digestive enzyme supplements. Using organic, systemic, Dr. formulated, & plant based ingredients to ensure the best healthy digestion for adult men & women. Anti bloating, flatulence, fat, pancreatic, & bowel cleansing with Turmeric, Ginger, Papaya, Pectin, Bladderwrack & more.
Goodbye Hard-to-Digest Foods – This formula features our Advanced Multi Enzyme System to help you digest fried, spicy, raw, processed food, dairy, protein, salts, carb / carbohydrate, vitamin and acidic diet fruits and veggies. Immune-Boosting Probiotic – The gut, biofilm & gallbladder is home to 50% of the body’s immune repair response and this supplement contains a powerful 10 billion CFU dose of 10 different probiotic strains clinically shown to enhance preventions & immune system response.
Relieve Gas, Belly Bloating / Bloat, Constipation, Leaky, Indigestion, Reflux, Belching & Acid Discomfort! Aid gut health, beauty & bloated stomach comfort. Prebiotic fiber, probiotic encapsulation(Lactobacillus acidophilus, plantarum, casei, salivarius, bulgaricus and Bifidobacterium lactis, bifidum, breve, longum), & enzymes support gut flora bacteria, bile, nutrient absorption, motility, & enzyme levels your body isn't producing as you age.
Complete digestive enzyme pills complex blend with essential organic blue agave heart, inulin, amylase / amilasa, papain, protease A, invertase, cellulase, hemicellulase, lactase, lipase / lipasa, alpha-galactosidase, fungal pepsin, glucomylase, & bromelina & bromelain supplement. Plus your probiotic supplement and prebiotic supplement (pre & pro) at the same time. All in a convenient purified cap / capsule form which you can open and take as a chewable with dietary nutrients, super food or meal
Proudly made in the USA in a GMP certified manufacturing facility, 3rd Party Tested, and a 100% satisfaction money back guarantee. If you are not satisfied with our products for any reason, let us know and we’ll make it right. This product is vegan, non-GMO, pure, natural, gluten free, cGMP, wise, dairy free, zen, organic ingredients and is free of soy, peanuts, eggs, gelatin, ox, shellfish, artificial sweeteners, colors, & flavors.

Bestseller No. 6

Pure Encapsulations Digestive Enzymes Ultra - Vegetarian Digestive Enzyme Supplement to Support Protein, Carb, Fiber, and Dairy Digestion* - 90 Capsules

Nutrient Absorption: Contains a mixture of vegetarian enzymes developed to support nutrient bioavailability and absorption; supports digestion*
Supports Digestion: Facilitates the normal breakdown of proteins, peptides, polysaccharides and disaccharides; assists with dairy, fiber, and protein digestion*
Digestive Enzymes: Offers a broad-spectrum combination of vegetarian digestive enzymes designed to provide optimal activity across a wide pH range
Dairy Enzyme Blend: This vegetarian enzyme blend supports digestion of dairy, sugar, lactose, and certain complex carbs; supports relief from occasional gas or bloating
Pure Difference: What we leave out matters, too; Pure Encapsulations products are free from common allergens, artificial or unnecessary ingredients, and GMOs

SaleBestseller No. 7

Garden of Life Dr Formulated Digestive Enzymes with Papain, Bromelain, Lipase for Digestion & Nutrient Absorption – Organic Digest+ - Vegan, Gluten-Free, Non-GMO, Tropical Fruit Flavor, 90 Chewables

BREAK IT DOWN: Organic Digest+ offers 29 Certified Organic fruits and vegetables plus a select blend of 13 powerful digestive enzymes including amylase, bromelain, and lactase to help with digestion after meals
MADE FROM WHOLE FOODS: Dr. Perlmutter formulated Digest+ to be a full spectrum plant-based enzyme formula to aid the digestion of proteins, fats, and carbs; We’ve also included prebiotic fiber from Organic Acacia to support the good bacteria in your gut
BACKED BY SCIENCE: Our Dr. Formulated Organic Digest+ is the first-ever Certified Organic and Non-GMO digestive enzyme formula that is made from real food and is delivered using Clean Tablet Technology to ensure optimal nutrient absorption
CONVENIENCE IN MIND: Transport to the tropics after every last bite; Enjoy the benefits of Organic Digest+ in a tropical flavored, shelf stable tablet thats size makes it easy to take on the go; Adults chew 1 tablet after each meal or snack
EXPERTLY FORMULATED: Our digestive supplement is proudly Dr. Formulated by David Perlmutter, MD and Third-Party Certified Non-GMO, Gluten-Free and Vegan; Made in the USA with no dairy, soy, gluten, peanuts or tree nuts

Bestseller No. 8

Pure Encapsulations Digestive Enzymes Ultra with Betaine HCl - Vegetarian Digestive Enzyme Supplement to Support Protein, Carb, Fiber, and Dairy Digestion* - 180 Capsules

Nutrient Absorption: Contains a mixture of vegetarian enzymes developed to support nutrient bioavailability and absorption; supports digestion*
Supports Digestion: Facilitates the normal breakdown of proteins, peptides, polysaccharides, and disaccharides; assists with dairy, fiber, and protein digestion*
Digestive Enzymes: Offers a broad-spectrum combination of vegetarian digestive enzymes designed to provide optimal activity across a wide pH range
Enhanced Enzyme Blend: Experience enhanced digestion aid with Betaine HCI; supports optimal gastric pH for normal breakdown of many food types*
Pure Difference: What we leave out matters, too; Pure Encapsulations products are free from common allergens, artificial or unnecessary ingredients, and GMOs

Bestseller No. 9

NatureBell Digestive Enzymes with Probiotics and Prebiotics, 240 Veggie Capsules | Gut & Digestive Health Support – 20 Enzyme & 5 Prebiotic Pancreatic Enzyme Complex | Non-GMO, Vegan Friendly

Digestive Enzyme and Prebiotic complex with 240 veggie capsules, one capsule serving for an 8-month supply, take one per meal daily for up to three meals for the first week, then only once daily after that for optimal benefits.
Each serving delivers 400mg total, combining 20 enzymes with 5 prebiotics including 200mg of psyllium husk, inulin, acacia senegal, FOS, and chia seed, as well as 200mg of carbs, proteins, fibers, fats, and lactose enzymes.
Designed for both women and men, this full spectrum blend supports digestion, nutrient absorption, bloating, and overall gut health.
A synergistic mix that may promote a balanced gut flora, providing daily digestive balance with its unique combination of enzymes and prebiotics.
Authentic non-GMO digestive enzyme supplement. Contains pure ingredients free of soy, dairy, gluten, wheat, preservatives, eggs, fish, and tree nuts. All products are also 3rd party lab tested for safety and potency.

Bestseller No. 10

Doctor's Best Digestive Enzymes, Support Healthy Digestion, Optimal Intestinal Health, Non-GMO, Vegetarian, Gluten Free, 90VC

Gluten-free
Non-GMO
One 90 count bottle of doctor's best digestive enzymes dietary supplement
Science-based nutrition
Vegetarian

Related Posts