10 Best dao enzyme supplements (2025)

DAO enzyme supplements are gaining popularity in 2025 for their potential to support histamine metabolism and alleviate symptoms of histamine intolerance. The 10 best DAO enzyme supplements this year include brands like Histamine Block, DAO Enzyme by Seeking Health, and Histamine Digest by Enzymedica, known for their high potency and quality ingredients. Other notable mentions are Pure Encapsulations DAO, Allergy Research Group DAO, and Doctor's Best Histamine Block. These supplements are formulated to enhance digestive health and improve overall well-being, making them essential for those sensitive to histamines. Always consult a healthcare professional before starting any new supplement regimen.

Bestseller No. 1

NATURDAO - 1,000,000 HDU - DAO Enzyme Supplement - Histamine Block - Diamine Oxidase - Food Intolerance - 60 Tablets

✔ GREATEST ENZYMATIC ACTIVITY ON THE MARKET with 1,000,000 HDUs / 32,1mg of vegetable protein, it is the most powerful DAO enzyme you can get to reinforce your digestive system.
✔ BEST NATURAL CHOICE if you are going to take it for a long period of time along with your diet. It is suitable for vegans.
✔ FAST AVAILABILITY TABLETS IN HUMAN INTESTINE tested by radiological test.
✔ This product contains nothing other than what is labeled. AVOID if allergic to any of the following ingredients: Cellulose (vegetable source), LEGUMACTIVE (Peas* Pisum Sativum, Lentils* Lens Culinaris), Hydroxypropylcellulose (vegetable source), Stearic Acid (vegetable source) and Silicon Dioxide (mineral). No food colours or genetically modified organisms.
✔ REFUND POLICY · Your well-being is our priority at NaturDao. To ensure utmost hygiene and safety, we don't accept returns. Unsatisfied with NaturDao? Reach out to us at naturdao.com with your order # for a hassle-free refund.

Bestseller No. 2

Ancestral Supplements Grass Fed Beef Kidney Supplement, 3000mg, DAO Enzyme Supplement, Kidney Support for Urinary and Histamine Health, Selenium, B12, Non GMO, 180 Capsules

TIME-HONORED KIDNEY SUPPLEMENTS: Grounded in the traditional wisdom of ancient practices, our kidney organ meat supplements are rich in kidney-specific proteins, peptides, enzymes and cofactors that support overall kidney health.
DAO SUPPLEMENTS: Ancestral Supplements' Kidney Health Capsules include naturally occurring diamine oxidase (DAO), as well as B12 and Selenium to support healthy histamine levels in the body.
WHOLE FOOD KIDNEY SUPPORT SUPPLEMENT: Our freeze-dried beef kidney health supplement offers nourishment that only whole foods can provide to promote urinary health and cleansing.
NEW ZEALAND AND AUSTRALIAN GRASS-FED BEEF: Made in small batches in the USA without GMOs, fillers, or flow agents and third party verified for purity, our supplements for kidney health are sourced from 100% grass fed cows, pasture-raised without hormones in green fields.
DENSE NUTRITION FOR VITALITY AND ENERGY: As the founders of the Beef Organ Movement, our mission is to make vital nutrition through the highest possible quality organ consumption accessible for all, putting back in what the modern world has left out.

SaleBestseller No. 3

Life Extension Food Sensitivity Relief with Diamine Oxidase (DAO), Occasional Gas, Digestive Comfort, histamine Sensitivity, DAO Enzyme Supplement, Gluten Free, Non-GMO, Vegetarian, 60 Capsules

Gastrointestinal comfort – Get relief from occasional gas and stomach upset, as well as other gastrointestinal discomforts caused by histamine-rich foods like cured meats, cheese and wine
Histamine metabolism – Diamine oxidase supports the healthy breakdown of intestinal histamine. This in turn helps relieve occasional non-allergy digestive discomfort associated with dietary histamine sensitivity.
Plant-based DAO – Many DAO formulas utilize enzymes derived from animals (usually pork). But our formula uses diamine oxidase from pea sprouts.
Ingredients matter – We use the finest raw ingredients with the quality and purity you deserve. The majority of our products are non-GMO, gluten-free and manufactured in the USA—and a Certificate of Analysis is available for every one.
Live your healthiest life – We believe the answers to a healthier life are in reach, and that scientific research is the key to getting there. That’s why so many of our formulas feature specific ingredients and amounts based on scientific studies.

Bestseller No. 4

Seeking Health Histamine Digest - Digestive Enzyme Support for Histamine Intolerance - DAO Supplement Aids Histamine Digestion for Stomach Relief - 30 Capsules

Digestive Enzyme Support: This digestion supplement formulated with patented DAO2 enzyme supports the healthy breakdown of histamine in many areas of your body
Fast-Acting Stomach Relief: For digestion support, take one supplement capsule just prior to consuming high histamine foods or drinks
Digest Histamine Support: This digestive enzyme supplement supports histamine already within a healthy range in the small intestines, colon, uterus, bladder, prostate and breast milk
Allergen-Friendly Gut Health Support: This histamine intolerance supplement is free of GMOs, gluten, eggs, fish, shellfish, tree nuts, peanuts, wheat, sesame, and soy
Optimizing Healthy Living: From research to packaging, Seeking Health prioritizes quality and safety at every step of the production process to provide health support you can trust

Bestseller No. 5

Omne Diem Histamine Digest DAO 30,000 HDU - 60 Caps - Histamine Neutralizing Enzyme - Relieve Histamine Intolerance with Diamine Oxidase

An Effective Enzyme Solution to Histamine Intolerance and Imbalance.
Alcoholic beverages - particularly red wine - present a triple threat to histamine sensitive people, because they contain histamine, they liberate histamine, and they block the action of DAO.
Diamine oxidase (DAO) is your body’s first-line defense against histamine ingested through the diet or released within the gut.
Take OmneDiem Histamine Neutralizing Enzyme about 15-30 minutes prior to consuming high histamine foods and beverages, to help your body break down histamine and reduce the reactions of histamine intolerance such as flushing, runny nose, sneezing, and digestive issues.
OmneDiem Histamine Neutralizing Enzyme is gluten-free, non-GMO, soy-free, non-dairy, food grade Diamine Oxidase - with no artificial preservatives or sweeteners.

Bestseller No. 6

XYMOGEN HistDAO - DAO Enzyme Supplement to Supports Healthy Degradation of Food-Derived Histamine - Diamine Oxidase for Digestive Health 20,000 HDU Per Serving (60 Tablets)

All You Need In One Tablet - Our digestive enzyme supplement is a formula containing 20,000 HDU of diamine oxidase (DAO) enzymes per tablet. This product has been reformulated from 2 capsules to 1 single tablet needed to get a full serving of dao.
Clinically Tested - Unlike standard digestive enzymes used for digestion support, this enzyme has been clinically tested and found to break down food-derived histamine in the digestive tract.*
Digestive Support - Enhances the presence of diamine oxidase enzyme in the digestive tract. DAO is not absorbed and does not have systemic activity.*
Multi-Benficial Supplement - This unique enzyme encompasses our immune support, digestive health and gastrointestinal support categories.*
Formulated to Exclude - Wheat, gluten, yeast, soy, dairy products, fish, shellfish, peanuts, tree nuts, egg, artificial colors, artificial sweeteners, and artificial preservatives. Our DAO supplements are practitioner trusted.

Bestseller No. 7

HISTAsolv Extra Strength DAO Enzyme Supplement for Histamine Food Intolerance - Eases Digestive Discomfort - Patented Tech - Made in Austria - 30 Pack

ENJOY THE FOODS YOU LOVE AGAIN: HISTAsolv provides fast, effective relief from histamine intolerance, helping you enjoy histamine-rich foods and drinks without the discomfort of symptoms like flushing, headaches, or digestive issues. Not for food allergies
MAXIMUM POTENCY & PERFORMANCE: Each high-potency tablet is nitrogen-packed in a sealed blister and foil pouch, protecting it from air degradation to ensure freshness and maximum histamine-fighting power
FAST AND CONVENIENT RELIEF: Take 1 tablet 15 minutes before consuming histamine-rich food or drink for quick results; Compact blister pack for on-the-go use; Love it or get an Amazon refund - no return required
PATENTED PRECISION COATING: Our enteric-coated tablets ensure HISTAsolv’s high-potency DAO enzyme survives stomach acid and reaches the small intestine, helping your body naturally break down histamine for maximum relief
SCIENTIFICALLY TESTED & MADE IN AUSTRIA: Each HISTAsolv Extra Strength tablet (36,000 HDUs) rapidly increases DAO levels in the small intestine to neutralize food histamine as it arrives; Gluten and Lactose Free

Bestseller No. 8

Designs for Health HistaGest-DAO - Diamine Oxidase DAO Enzyme to Support Digestion of Histamine-Containing Foods - 20,000 HDU DAO Diamine Oxidase Enzymes (60 Gastro-Resistant Tablets)

Support Digestion of Food‑Derived Histamines - Lower DAO activity may result in higher levels of histamine being absorbed through the small intestine and accumulating in the blood. HistaGest-DAO provides supplemental diamine oxidase enzyme. Unlike common digestive enzyme products, this enzyme is responsible for breaking down food-derived histamine to help support normal and healthy histamine metabolism.*
Convenient 'Take-Anywhere' Dispenser - This DAO supplement offers small tablet delivery in a convenient travel dispenser for portability and ease of use when on‑the‑go. Each tablet provides 20,000 histamine-degrading units (HDU) of diamine oxidase (DAO) from porcine kidney extract to promote the degradation of dietary histamines.*
Just Take One Before Histamine-Rich Foods - Taking one diamine oxidase DAO supplement tablet before each meal promotes the amount of DAO in the small bowel to help break down histamine in the digestive tract, support digestive health and soothe digestive discomfort associated with sensitivity to histamine-rich foods.*
Delayed-Release Tablets Designed for High Performance - DAO supplements can be less effective if they do not reach the small intestine. HistaGest-DAO diamine oxidase supplement is made with gastro-resistant, coated tablets with delayed-release technology that allows the DAO enzyme to reach the small intestine where it performs its action.*
Clinically-Trusted Care - DFH is the #1 practitioner supplement brand recommended by functional medicine professionals and the #1 practitioner supplement brand personally trusted by functional medicine professionals.**

Bestseller No. 9

NATURDAO Plus – 1,000,000 HDU per dose - DAO Enzyme and Catalase Enzyme - 8 Cofactors and Adjuvants to Help Boost Your Own DAO - Advanced Histamine Blocking Formula - Food Intolerance - 60 Tablets

✔ BOOST YOUR DAO · Experience a potent lift in your body's DAO levels with NaturDao Plus, designed for superior histamine breakdown and enhanced absorption. Simple and strong!
✔ NATURDAO PLUS offers the perfect combination of science, innovation and a premium LegumActive formula. It is cruelty-free, gluten-free, GMO-free, and 100% vegan.
✔ MAXIMUM BIOAVAILABILITY · Naturdao Plus is formulated to maximize the absorption of all of its ingredients. This is done by activating the ingredients through methylation, phytosomization, and liposomization.
✔ ESSENTIAL ACTIVATED INGREDIENTS · CO-FACTORS: Liposomal Ascorbic Acid, Zinc, Methylated Pyridoxal-5-Phosphate and Copper. ADJUVANTS: Phytosome Quercetin, Methylated 5-Methyltetrahydrofolate, Methylcobalamin and Catalase.
✔ ATTENTION This product contains nothing other than what is labeled. AVOID if allergic to any of the ingredients printed on the label. No food colours or genetically modified organisms.

Bestseller No. 10

Paramount Labs Premium Diamine Oxidase DAO Supplements Histamine Blocker - Food-Derived Histamine Intolerance Relief - DAO Enzyme Supplements - Made in USA - 30 ct

Feel True Comfort – Our DAO supplements histamine blocker targets histamines directly, reducing discomfort before it starts. It supports your intestinal health, mucous membranes, and clear airways.
Enjoy Your Favorite Foods – With our DAO supplement, you can enjoy histamine-rich foods like wine and cheese without worry. Our natural antihistamine boosts Diamine Oxidase (DAO) levels to help your body break down histamines.
Achieve Digestive Harmony – Our DAO Enzyme Supplements curbs histamine intolerance discomfort, strengthening your intestinal lining and ensuring digestive harmony.
Top Quality You Can Trust – Every Paramount Labs capsule is made with your health in mind. Our histamine digest formulation is free from major food allergens, gluten-free, and made with non-GMO ingredients.
Paramount Labs Promise – Our histamine block supplement offers relief or a full purchase back within 365 days. Enjoy your favorite foods without histamine concerns!

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