10 Best arthritis cream (2025)

10 Best arthritis cream options for 2025 offer effective relief for joint pain and inflammation. These creams are formulated with powerful ingredients like menthol, capsaicin, and natural extracts to soothe discomfort and improve mobility. Top contenders include products from brands like Biofreeze, Aspercreme, and Penetrex, known for their fast-acting and long-lasting effects. Many of these creams are non-greasy and easy to apply, making them convenient for daily use. Whether you’re dealing with osteoarthritis or rheumatoid arthritis, these creams provide targeted relief, helping you regain your quality of life and stay active.

Bestseller No. 1

Voltaren Arthritis Pain Gel for Powerful Topical Arthritis Pain Relief, No Prescription Needed - 1.7 oz/50 g Tube

One 1.7 oz/50 g tube of Voltaren Arthritis Pain Gel for Powerful Topical Arthritis Pain Relief
Number 1 Doctor Recommended topical pain relief brand
Clinically Proven to relieve arthritis pain, improve mobility and reduce stiffness, aches and pains to provide prescription strength arthritis pain relief
An Alternative to Pills, Voltaren is a nonsteroidal anti-inflammatory gel that combines the benefits of an arthritis cream and gel for arthritis pain management
Diclofenac Sodium Topical Gel Penetrates Deep to attack arthritis pain directly at the source of inflammation, treating arthritis pain

Bestseller No. 2

Voltaren Arthritis Pain Gel for Powerful Topical Arthritis Pain Relief - NEW Easy Open Cap - 150 g

One 5.3 oz/150 g tube of Voltaren Arthritis Pain Gel for Powerful Topical Arthritis Pain Relief- Easy flip cap that can be opened with your palm, fingers, or even with just one hand; packaging may vary
Number 1 Doctor Recommended topical pain relief brand
Clinically Proven to relieve arthritis pain, improve mobility and reduce stiffness, aches and pains to provide prescription strength arthritis pain relief
An Alternative to Pills, Voltaren is a nonsteroidal anti-inflammatory gel that combines the benefits of an arthritis cream and gel for arthritis pain management
Voltaren Arthritis Pain Gel Penetrates Deep to attack arthritis pain directly at the source of inflammation, treating arthritis pain

SaleBestseller No. 3

Voltaren Arthritis Pain Gel for Powerful Topical Arthritis Pain Relief - NEW Easy Open Cap - 100 g x 2

Two 3.5 oz/100 g tubes of Voltaren Arthritis Pain Gel for Powerful Topical Arthritis Pain Relief- Easy flip cap that can be opened with your palm, fingers, or even with just one hand; packaging may vary
Number 1 Doctor Recommended topical pain relief brand
Clinically Proven to relieve arthritis pain, improve mobility and reduce stiffness, aches and pains to provide prescription strength arthritis pain relief
An Alternative to Pills, Voltaren is a nonsteroidal anti-inflammatory gel that combines the benefits of an arthritis cream and gel for arthritis pain management
Voltaren Arthritis Pain Gel Penetrates Deep to attack arthritis pain directly at the source of inflammation, treating arthritis pain rather than just masking it

SaleBestseller No. 4

HealthCareAisle Diclofenac Gel, 1%, Arthritis Pain Relief - 100 g tube - Original Prescription Strength (NSAID)

Arthritis pain relief medicine: Diclofenac Sodium Topical Gel 1% is clinically proven to relieve arthritis pain
Diclofenac Sodium Topical Gel 1% is a Non-Steroidal Anti-Inflammatory Drug (NSAID) that provides temporary relief of arthritis pain by penetrating the skin to target painful inflammation in the hand, wrist, elbow, foot, ankle and knee
Comparable to the national brand: Has the same active ingredient in Voltaren Arthritis Pain Gel*
Apply 4 times per day for up to 21 days to temporarily relieve arthritis pain or as directed by your doctor; do not use on more than 2 body areas at the same time
See package label for warnings, directions and other important information; use only as directed

Bestseller No. 5

Amazon Basic Care Arthritis Pain Relieving Gel, Diclofenac Sodium Topical Gel, 1% (NSAID), 5.29 Oz (150 Grams) (Packaging may vary)

ACTIVE INGREDIENT: This arthritis pain reliever contains diclofenac sodium, an NSAID (non-steroidal anti-inflammatory drug) 1 percent (equivalent to 0.93 percent diclofenac); compare to the active ingredient in Voltaren Arthritis Pain
ARTHRITIS PAIN RELIEF: For the temporary relief of arthritis pain ONLY in the following areas: hand, wrist, elbow (upper body areas); foot, ankle and knee (lower body areas)
FOR DAILY ARTHRITIS PAIN: Use Amazon Basic Care Arthritis Pain Relieving Gel daily for the treatment of arthritis pain to keep you going strong; clinically proven to relieve arthritis pain
ANTI-INFLAMMATORY: Amazon Basic Care Arthritis Pain Relieving Gel contains an NSAID (non-steroidal anti-inflammatory drug) to help relieve hand, wrist, elbow, foot, ankle and knee arthritis pain
HOW TO USE: For arthritis pain only; use 4 times a day; may take up to 7 days to work for your arthritis pain; for use on no more than 2 body areas; use up to 21 days unless directed by your doctor; see product labeling for full directions prior to use

Bestseller No. 6

Voltaren Arthritis Pain Gel for Powerful Topical Arthritis Pain Relief - NEW Easy Open Cap - 100 g Tube And 20 g Travel Size Tube

One 3.5 oz/100 g tube and one 0.71 oz/20 g travel size tube of Voltaren Arthritis Pain Gel for Powerful Topical Arthritis Pain Relief- Easy flip cap that can be opened with your palm, fingers, or even with just one hand; packaging may vary
Number 1 Doctor Recommended topical pain relief brand
Clinically Proven to relieve arthritis pain, improve mobility and reduce stiffness, aches and pains to provide prescription strength arthritis pain relief
An Alternative to Pills, Voltaren is a nonsteroidal anti-inflammatory gel that combines the benefits of an arthritis cream and gel for arthritis pain management
Voltaren Arthritis Pain Gel Penetrates Deep to attack arthritis pain directly at the source of inflammation, treating arthritis pain rather than just masking it

SaleBestseller No. 7

Boiron Arnicare Arthritis Cream with Devil’s Claw for Pain Relief of Knees, Hands, Wrists, Elbows, Joints & Muscles – Quickly Absorbed & Fragrance-Free – 2.5 oz

DUAL ACTION: Scientifically formulated with Arnica Montana and Harpagophytum (Devil’s Claw) for dual action pain relief. Addresses minor arthritis pain at its source and is suitable for use on all joints.
TOPICAL PAIN RELIEF: The non-greasy light, silky texture quickly absorbs into skin is ideal for sudden flare-ups and soreness.
PLANT-BASED ACTIVE INGREDIENT: Arnica Montana and Harpagophytum are natural pain relievers. No camphor, menthol, or other ingredients that cause burning or stinging and is paraben-free.

Bestseller No. 8

Australian Dream Arthritis Pain Relief Cream - Soothing, Non-Greasy Pain Relief Cream - Powerful Topical Arthritis Pain Relief Good for Muscle Aches or Joint Pain - 4 oz Jar

Soothing Pain Relief: Our Australian Dream Arthritis Pain Relief Cream is easily absorbed, providing a powerful, effective formula for muscle and joint pains
Powerful, Economical Relief: Our cream provides a powerful solution to your arthritis pain, and it doesn't take much to do the job
Odorless & Non-Greasy: Our arthritis pain relief cream is non-greasy, odorless, and doesn't burn, making it perfect for sore muscles and painful joints
High-Quality Formula: With histamine dihydrochloride, this pain cream provides temporary relief of minor aches and pains of muscles and joints associated with arthritis, simple backache, strains, sprains, and bruises
Moving is Living: Australian Dream is dedicated to relieving pain and promoting comfort; this dedication is why we’re America’s first premium topical analgesic pain reliever

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