10 Best anti itch cream (2025)

10 Best anti-itch creams of 2025 offer effective relief for various skin irritations, ensuring comfort and soothing sensations. These top-rated products feature powerful ingredients like hydrocortisone, calamine, and natural extracts to combat itching caused by allergies, insect bites, and dry skin. Brands such as Aveeno, Cortizone-10, and Eucerin lead the market with their dermatologist-recommended formulas. Additionally, many of these creams are designed for sensitive skin, providing gentle yet effective solutions. Whether you’re dealing with eczema or seasonal allergies, these creams promise to alleviate discomfort and restore skin health, making them essential for your first-aid kit.

Bestseller No. 1

Cortizone 10 Maximum Strength Anti-Itch Cream with Soothing Aloe, 1% Hydrocortisone Creme, 2 oz.

Contains: One (1) 2-oz. tube of Cortizone 10 Maximum Strength Soothing Aloe Anti-Itch Cream
Fast relief of itch and inflammation associated with eczema, psoriasis, and poison oak, ivy, and sumac
Features 1 percent hydrocortisone, the maximum-strength itch relief without a prescription
Relieves itch in under 10 minutes and lasts for hours
Cortizone 10 anti-itch cream with aloe is fragrance free and dye free

Bestseller No. 2

Amazon Basic Care Maximum Strength Anti-Itch Cream, Hydrocortisone 1 Percent Intensive Healing Formula, Itch Relief For Bug Bites, Eczema, Psoriasis, Poison Ivy, Oak and Sumac, 1 ounce (Pack of 1)

ACTIVE INGREDIENT: The active ingredient in this anti-itch cream is hydrocortisone 1 percent; compare to the active ingredient in Cortizone 10 Intensive Healing Formula
MAXIMUM STRENGTH RELIEF: Hydrocortisone is the number one doctor recommended anti-Itch active Ingredient (of U.S. physicians surveyed by an independent market research firm)
POWERFUL MEDICINE, FAST RELIEF: Great for relieving itching associated with skin irritation, rashes, inflammation, redness, insect bites, eczema, psoriasis and poison ivy, oak and sumac
LASTS UP TO 10 HOURS when used as directed; ultra creamy, maximum strength hydrocortisone formula helps heal problem skin; safe for sensitive skin; for adults and children age 2 years of age and older
INTENSIVE HEALING FORMULA calms, nourishes and hydrates; clinically proven to moisturize for up to 24 hours; features antioxidants, chamomile and Vitamins A, C and E

SaleBestseller No. 3

Globe (4 Pack) Hydrocortisone Maximum Strength Anti-Itch Cream 1% w/Aloe, Intensive Formula for Redness, Rash, Bug & Mosquito Bites, Eczema, Hemorrhoids, Sensitive Skin, Instant Itch Relief,1 oz Tube

MAXIMUM STRENGTH FORMULA: Globe Hydrocortisone Cream 1% with Aloe combines powerful hydrocortisone with soothing aloe for rapid relief from itching, redness, and irritation. Ideal for eczema, psoriasis, insect bites, and more.
FAST ITCH RELIEF: Provides fast relief from skin irritation, rashes, redness, and bug bites. Helps with poison ivy, oak, sumac, and other skin conditions. Perfect for easing symptoms of dermatitis and reducing swelling.
ESSENTIAL FOR HOME & TRAVEL: Keep this hydrocortisone cream in your home, car, or travel kit. Cleanse the affected area with mild soap and apply up to 4 times daily for immediate alleviation from itching and redness.
PHARMACIST RECOMMENDED: Hydrocortisone is highly effective in easing symptoms of eczema, psoriasis, and dermatitis, particularly itching, redness, and discomfort. Safe to use for insect bites and rashes caused by poison ivy and oak, offering reliable alleviation from irritated skin.
PREMIUM QUALITY MANUFACTURING: Manufactured in USFDA-audited facilities, Globe products meet the highest pharmaceutical standards. Compare to leading name brand ingredients for cost-effective, reliable relief.

SaleBestseller No. 4

CeraVe Moisturizing Cream for Dry Skin Relief | 12 Ounce | Fragrance Free Cream with Pramoxine for Itch Relief

[ CERAVE ANTI ITCH CREAM ] Temporarily relieves itching associated with insect bites, sunburn, poison ivy while moisturizing dry skin. Rich, velvety texture that is absorbed quickly for softened skin with non-greasy feel.
[ CLINICALLY TESTED ] Provides relief within two minutes and lasts up to 8 hours. 100 percent of people experienced relief for even their most severe itch; clinical study done on 34 subjects. Individual results may vary.
[ SOOTHING INGREDIENTS ] Formulated with 1% Pramoxine Hydrochloride for fast-acting, long-lasting temporary itch-relief, Niacinamide to help calm skin, and Hyaluronic Acid to help retain skin’s natural moisture.
[ 3 ESSENTIAL CERAMIDES ] Ceramides are found naturally in the skin and make up 50% of the lipids in the skin barrier. All CeraVe products are formulated with three essential ceramides (1, 3, 6-II) to help restore and maintain the skin’s natural barrier
[ DEVELOPED WITH DERMATOLOGISTS ] Suitable for use on face, body, and hands to temporarily relieve itching. Holds National Eczema Association (NEA) Seal of Acceptance. Fragrance free, steroid-free, and non-comedogenic. FSA Eligible & HSA Eligible

SaleBestseller No. 5

Benadryl Extra Strength Anti-Itch Topical Cream with 2% Diphenhydramine HCI for Itch Relief of Outdoor Itches Associated with Poison Ivy, Insect Bites & More, 1 fl oz

1-ounce tube of Benadryl Extra-Strength Anti-Itch Cream temporarily relieves pain and itching associated with insect bites, minor burns, sunburn, minor skin irritations, minor cuts, scrapes and rashes due to poison ivy, poison oak and poison sumac
Topical analgesic cream works when you need it most and provides cooling, anti-itch relief from most minor pains and outdoor itches associated with insect bites, sunburn, scrapes, minor skin irritations, burns and minor cuts
The cooling cream provides the relief of pain and itching associated with sunburn, relieves outdoor itches associated with poison ivy, insect bites and more and dries the oozing and weeping of poison ivy, poison oak and poison sumac
Cooling cream that provides relief from most outdoor itches contains 2% of the topical analgesic pain reliever diphenhydramine hydrochloride that relieves itches and minor pains on the skin and works when you need it most
Intended for use by those ages 2 and up, soothing cream offers itch relief for kids and adults alike and is great to keep on hand for relief during outdoor activities such as camping, hiking or taking a walk with the family

Bestseller No. 6

CeraVe Anti Itch Moisturizing Lotion with Pramoxine Hydrochloride | Relieves Itch with Minor Skin Irritations, Sunburn Relief, Bug Bites | 8 Ounce

[ CERAVE ANTI ITCH LOTION ] Temporarily relieves itching associated with insect bites, sunburn, poison ivy while moisturizing dry skin. Lightweight texture that is absorbed quickly for softened skin with non-greasy feel.
[ CLINICALLY TESTED ] Provides relief within two minutes and lasts up to 8 hours. 100 percent of people experienced relief for even their most severe itch; clinical study done on 34 subjects. Individual results may vary.
[ SOOTHING INGREDIENTS ] Formulated with 1% Pramoxine Hydrochloride for fast-acting, long-lasting temporary itch-relief, Niacinamide to help calm skin, and Hyaluronic Acid to help retain skin’s natural moisture.
[ 3 ESSENTIAL CERAMIDES ] Ceramides are found naturally in the skin and make up 50% of the lipids in the skin barrier. All CeraVe products are formulated with three essential ceramides (1, 3, 6-II) to help restore and maintain the skin’s natural barrier
[ DEVELOPED WITH DERMATOLOGISTS ] Suitable for use on face; body; and hands to temporarily relieve itching. Holds National Eczema Association (NEA) Seal of Acceptance. Fragrance free; steroid-free; and non-comedogenic. FSA Eligible & HSA Eligible

SaleBestseller No. 7

Aquaphor Itch Relief Ointment, Maximum Strength 1% Hydrocortisone, Relieves Itch from Skin Irritation, Insect Bites, Psoriasis, Skin Rashes, Eczema, & Poison Ivy, 2 oz

Long Lasting Itch Relief: Aquaphor Itch Relief ointment soothes and relieves itch and irritation for up to 12 hours
Outdoor Irritation Relief: Clinically proven to help provide instant itch relief for outdoor irritations like insect bites, poison ivy, poison oak, and sumac
Indoor Itch Relief: This skin ointment can also help to soothe and relieve itchiness from indoor causes like dry skin, skin rash, and psoriasis
Helps Heal the Itch: Formula features 1% hydrocortisone anti itch ointment, and is fragrance free, paraben free, and hypoallergenic
Includes one (1) 2 ounce tube of Aquaphor Itch Relief Ointment

SaleBestseller No. 8

Benadryl Anti Itch Gel, Relief of Outdoor Itches Associated with Poison Ivy, Topical Analgesic, Cooling Relief, Diphenhydramine, 3.5 oz

ANTI ITCH GEL: Benadryl anti itch gel temporarily provides pain and itch relief associated with insect bites, minor burns, sunburn, minor skin irritation, minor cuts and scrapes, and rashes due to poison ivy and poison sumac.
TOPICAL ANALGESIC: Topical cooling gel contains 2% of the topical analgesic pain reliver diphenhydramine hydrochloride that helps to relieve itches and minor pains on the skin; Provides relief from most outside itches.
SOOTHING & COOLING GEL: Carry this topical anti itch analgesic gel to relieve uncomfortable skin irritation at home or on the go; Works when you need it most and provides cooling relief from minor pain to intolerable itchy skin.
POISON IVY REIEF: Topical Analgesic to provide itch relief for most outdoor itches associated with poison ivy, insect bites; Dries the oozing and weeping of poison ivy, poison oak and poison sumac.
INCLUDES: Pack of 1, 3.5 fl. oz. anti itch gel; Suitable for adults and children ages 2+; Provides itch relief for kids and adults alike and great to keep on hand during outdoor activities such as camping, hiking, or walking with the family.

SaleBestseller No. 9

Sarna Sensitive Steroid-Free Anti-Itch Lotion for Dry Irritated Skin, Fragrance free - 7.5 Fl Oz

Intensive relief - Soothes itching from eczema and dry skin conditions
Targeted relief - Can be applied directly to the site of the itching for targeted relief
Designed for sensitive skin - Contains no steroids, no parabens and no fragrances
Daily moisturizer - Helps restore moisture to skin and is gentle enough for daily use

SaleBestseller No. 10

Cortizone 10 Maximum Strength Intensive Moisture Anti-Itch Cream, 1% Hydrocortisone, 2 oz.

Contains: One (1) 2-oz. tube of Cortizone-10 Maximum Strength Intensive Moisture Anti-Itch Cream
Fast relief of itch associated with minor skin irritations like rough, dry, chafed and chapped skin
Formulated with seven moisturizers, plus vitamins A, C, and E to nourish and hydrate skin
Features 1% hydrocortisone, the maximum-strength itch relief without a prescription
Relieves itch in under 10 minutes and lasts for hours

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